análise de dados de RNA-SEQ com datasets de estudo sobre hipercolesterolemia familiar: uma abordagem complementar e comparativa

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dc.contributor.advisorDalmolin, Rodrigo Juliani Siqueira
dc.contributor.advisorIDhttps://orcid.org/0000-0002-1688-6155pt_BR
dc.contributor.advisorLatteshttp://lattes.cnpq.br/4065178015615979pt_BR
dc.contributor.authorOliveira, Davi Rodrigues de
dc.contributor.authorIDhttps://orcid.org/0009-0009-5024-6993pt_BR
dc.contributor.authorLatteshttp://lattes.cnpq.br/0345921294013739pt_BR
dc.contributor.referees1Farias Filho, Epitácio Dantas de
dc.contributor.referees1IDhttps://orcid.org/0000-0002-3865-5411pt_BR
dc.contributor.referees1Latteshttp://lattes.cnpq.br/4326200607523374pt_BR
dc.contributor.referees2Martins, Daniella Regina Arantes
dc.contributor.referees2IDhttps://orcid.org/0000-0002-1350-5919pt_BR
dc.contributor.referees2Latteshttp://lattes.cnpq.br/3695151190501921pt_BR
dc.date.accessioned2025-01-17T22:07:49Z
dc.date.available2025-01-17T22:07:49Z
dc.date.issued2025-01-07
dc.description.resumoFamilial hypercholesterolemia (FH) is an autosomal dominant disease of genetic origin that directly increases levels of low-density lipoprotein (LDL-c). Due to its LDL-c alteration profile, FH increases the chances of developing atherosclerotic diseases, such as atherosclerotic heart disease (ICD-10 I.25.1) and atherosclerotic cardiovascular disease (ICD-10 I.25.0). Consequently, the primary treatment for FH is commonly the use of a maximum statin dosage. Utilizing a set of RNA-Seq public data from a study on the use of statins in patients with FH and an epidemiological dataset on ICD-10 I25.1 deaths, our objective is to carry out an RNA-Seq data analysis, integrating with information described in the literature and correlated epidemiological insights, in order to bring new perspectives that have not yet been proposed. A thorough analysis of epidemiological data obtained from public databases revealed that 2017 was the year with the highest number of ICD-10 I.25.1 death notifications, while 2020 and 2021 were the years with the lowest number of notifications. Furthermore, age and sex analyses indicated higher male mortality and an increase in deaths with age, with notable reductions among individuals over 80 during the pandemic. Finally, the analysis of RNA-Seq data revealed 15 altered genes in the ”before and after” comparison of statin use, as determined by concatenating the results of the three methods used (DGE, DTE, and DTU). Of these 15 altered genes, we identified two (LMBRD2 and HFE) that suggested new anti-atherosclerotic mechanisms promoted by statinspt_BR
dc.identifier.citationOLIVEIRA, Davi Rodrigues de. análise de dados de RNA-SEQ com datasets de estudo sobre hipercolesterolemia familiar: uma abordagem complementar e comparativa. Orientador: Rodrigo Juliani Siqueira Dalmolin. 2025. 28f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal/RN, 2025.pt_BR
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/61312
dc.languageenpt_BR
dc.publisherUniversidade Federal do Rio Grande do Nortept_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentDepartamento de Farmáciapt_BR
dc.publisher.initialsUFRNpt_BR
dc.publisher.programFarmáciapt_BR
dc.rightsAttribution-NonCommercial 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/br/*
dc.subjectHipercolesterolemia familiar homozigotapt_BR
dc.subjectAnálise de expressão diferencialpt_BR
dc.subjectRNA-Seqpt_BR
dc.subjectStatinpt_BR
dc.subjectFamilial hypercholesterolemiapt_BR
dc.subjectDifferential expression analysispt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDE::FARMACIApt_BR
dc.titleanálise de dados de RNA-SEQ com datasets de estudo sobre hipercolesterolemia familiar: uma abordagem complementar e comparativapt_BR
dc.title.alternativeRNA-SEQ data analysis with study datasets on familial hypercholesterolemia: a complementary and comparative approachpt_BR
dc.typebachelorThesispt_BR

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