Switch of innate to adaptative immune responses in the brain of patients with Alzheimer's disease correlates with tauopathy progression
| Author | Costa, Marcos Romualdo | |
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| Publisher | Npj Aging | |
| Date | 2024 | |
| Keywords | Alzheimer disease Neuroinflammatory diseases Microglia CD8-Positive T-Lymphocytes Tauopathies RNA-Seq Single-cell analysis | |
| Citation | ||
| Abstract | Neuroinflammation is a key feature of Alzheimer's disease (AD). In this work, analysis of single- cell RNA-sequencing (scRNA-seq) data obtained from the brain of patients with AD provides evidence supporting a switch from an innate to an adaptative immune response during tauopathy progression, with both disease-associated microglia (DAM) and CD8+ T cells becoming more frequent at advanced Braak stages | |
| URI | https://repositorio.ufrn.br/handle/123456789/67689 | |
| Collections | ICe - Artigos publicados em periódicos |
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