Switch of innate to adaptative immune responses in the brain of patients with Alzheimer's disease correlates with tauopathy progression
| dc.contributor.author | Costa, Marcos Romualdo | |
| dc.contributor.authorID | https://orcid.org/0000-0002-4928-2163 | |
| dc.date.accessioned | 2026-01-14T13:57:42Z | |
| dc.date.available | 2026-01-14T13:57:42Z | |
| dc.date.issued | 2024 | |
| dc.description.resumo | Neuroinflammation is a key feature of Alzheimer's disease (AD). In this work, analysis of single- cell RNA-sequencing (scRNA-seq) data obtained from the brain of patients with AD provides evidence supporting a switch from an innate to an adaptative immune response during tauopathy progression, with both disease-associated microglia (DAM) and CD8+ T cells becoming more frequent at advanced Braak stages | |
| dc.identifier.citation | COSTA, Marcos Romualdo. Switch of innate to adaptative immune responses in the brain of patients with Alzheimer’s disease correlates with tauopathy progression. Npj Aging, [S. l.], v. 10, n. 1, p. 19, mar. 2024. Doi: http://dx.doi.org/10.1038/s41514-024-00145-5. Disponível em: https://www.nature.com/articles/s41514-024-00145-5. Acesso em: 13 jan. 2026 | |
| dc.identifier.doi | 10.1038/s41514-024-00145-5 | |
| dc.identifier.uri | https://repositorio.ufrn.br/handle/123456789/67689 | |
| dc.language.iso | en | |
| dc.publisher | Npj Aging | |
| dc.rights | Attribution 3.0 Brazil | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/br/ | |
| dc.subject | Alzheimer disease | |
| dc.subject | Neuroinflammatory diseases | |
| dc.subject | Microglia | |
| dc.subject | CD8-Positive T-Lymphocytes | |
| dc.subject | Tauopathies | |
| dc.subject | RNA-Seq | |
| dc.subject | Single-cell analysis | |
| dc.title | Switch of innate to adaptative immune responses in the brain of patients with Alzheimer's disease correlates with tauopathy progression | |
| dc.type | article |