Anticoagulant, antioxidant and antitumor activities of heterofucans from the seaweed Dictyopteris delicatula

Magalhaes, Kaline Dantas; Costa, Leandro Silva; Fidelis, Gabriel Pereira; Oliveira, Ruth Medeiros; Nobre, Leonardo Thiago Duarte Barreto; Dantas-Santos, Nednaldo; Câmara, Rafael Barros Gomes da; Albuquerque, Ivan Rui Lopes; Cordeiro, Sara Lima; Sabry, Diego Araujo; Costa, Mariana Santana Santos Pereira; Alves, Luciana Guimaraes; Rocha, Hugo Alexandre de Oliveira

Anticoagulant, antioxidant and antitumor activities of heterofucans from the seaweed Dictyopteris delicatula

Página do item simplificado Estatísticas

dc.contributor.author	Magalhaes, Kaline Dantas
dc.contributor.author	Costa, Leandro Silva
dc.contributor.author	Fidelis, Gabriel Pereira
dc.contributor.author	Oliveira, Ruth Medeiros
dc.contributor.author	Nobre, Leonardo Thiago Duarte Barreto
dc.contributor.author	Dantas-Santos, Nednaldo
dc.contributor.author	Câmara, Rafael Barros Gomes da
dc.contributor.author	Albuquerque, Ivan Rui Lopes
dc.contributor.author	Cordeiro, Sara Lima
dc.contributor.author	Sabry, Diego Araujo
dc.contributor.author	Costa, Mariana Santana Santos Pereira
dc.contributor.author	Alves, Luciana Guimaraes
dc.contributor.author	Rocha, Hugo Alexandre de Oliveira
dc.date.accessioned	2021-01-29T19:39:11Z
dc.date.available	2021-01-29T19:39:11Z
dc.date.issued	2011-05-23
dc.description.resumo	In the present study, six families of sulfated polysaccharides were obtained from seaweed Dictyopteris delicatula by proteolytic digestion, followed by acetone fractionation and molecular sieving on Sephadex G-100. Chemical analyses demonstrated that all polysaccharides contain heterofucans composed mainly of fucose, xylose, glucose, galactose, uronic acid, and sulfate. The fucans F0.5v and F0.7v at 1.0 mg/mL showed high ferric chelating activity (~45%), whereas fucans F1.3v (0.5 mg/mL) showed considerable reducing power, about 53.2% of the activity of vitamin C. The fucan F1.5v presented the most prominent anticoagulant activity. The best antiproliferative activity was found with fucans F1.3v and F0.7v. However, F1.3v activity was much higher than F0.7v inhibiting almost 100% of HeLa cell proliferation. These fucans have been selected for further studies on structural characterization as well as in vivo experiments, which are already in progress	pt_BR
dc.identifier.citation	MAGALHÃES, Kaline Dantas; COSTA, Leandro Silva; FIDELIS, Gabriel Pereira; OLIVEIRA, Ruth Medeiros; NOBRE, Leonardo Thiago Duarte Barreto; DANTAS-SANTOS, Nednaldo; CAMARA, Rafael Barros Gomes da; ALBUQUERQUE, Ivan Rui Lopes; CORDEIRO, Sara Lima; SABRY, Diego Araujo; COSTA, Mariana Santana Santos Pereira; ALVES, Luciana Guimaraes; ROCHA, Hugo Alexandre de Oliveira. Anticoagulant, antioxidant and antitumor activities of heterofucans from the seaweed Dictyopteris delicatula. International Journal of Molecular Sciences, [s. l.], v. 12, p. 3352-3365, 2011. http://dx.doi.org/10.3390/ijms12053352. Disponível em: https://www.mdpi.com/1422-0067/12/5/3352. Acesso em: 25 set. 2020.	pt_BR
dc.identifier.doi	10.3390/ijms12053352
dc.identifier.issn	1422-0067 (online)
dc.identifier.issn	1661-6596 (print)
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31328
dc.language	en	pt_BR
dc.publisher	MDPI	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	Fucoidan	pt_BR
dc.subject	Brown seaweed	pt_BR
dc.subject	Biological activities	pt_BR
dc.subject	Sulfated polysaccharides	pt_BR
dc.title	Anticoagulant, antioxidant and antitumor activities of heterofucans from the seaweed Dictyopteris delicatula	pt_BR
dc.type	article	pt_BR