Análise das interações medicamentosas em psiquiatria: uma abordagem sobre as prescrições de pacientes internados

Abstract

Drug interactions are characterized by the alterations of the clinical effects of a medication due to its simultaneous use with other substances. These effects can be desirable or undesirable. Over the years, it's perceptible to increasing in the number of people who suffer some kind of mental disorder and in consequence the use of medications that treat clinical demonstrations. The objective of this study was to analyze the prescribed medication for psychiatric patient admitted to a psychiatric hospital and confront with literature, seeking to identify medication medicated interactions. It's a case study, prospective. The data for the research was collected at the institution's own central pharmacy. The verification of potential medicated interactions was done through the Micromedex database. The most prescribed psychotropic medicines classes were antipsychotic. The haloperidol was the most prescribed psychotropic medicine. Complex B and the promethazine were among the most prescribed general medications. They've accounted for a total of 25 medals, with an average of approximately 1.78% prescription records. Among them were accounted for 19 different medicines interactions. About 73.68% of interactions were considered larger gravity, 21.05% moderate gravity and 5.26% of interactions the medications had its concomitant use contraindicated. The study identified a high prevalence of potential drug interactions, most of which are more serious interactions. A high presence of prescription of antipsychotic drugs was also found, and most of them were affected in drug interactions.