Keratins 17 and 19 expression as prognostic markers in oral squamous cell carcinoma

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dc.contributor.authorCoelho, B. A.
dc.contributor.authorPeterle, G. T.
dc.contributor.authorSantos, Marcelo dos
dc.contributor.authorAgostini, Lidiane Pignaton
dc.contributor.authorMaia, L. L.
dc.contributor.authorStur, E.
dc.contributor.authorSilva, C. V. M.
dc.contributor.authorMendes, Suzanny Oliveira
dc.contributor.authorAlmança, Carlos Cesar Jorden
dc.contributor.authorFreitas, Flávia Vitorino
dc.contributor.authorBorçoi, Aline Ribeiro
dc.contributor.authorArchanjo, Anderson Barros
dc.contributor.authorMercante, A. M. C.
dc.contributor.authorNunes, Fabio Daumas
dc.contributor.authorCarvalho, M. B.
dc.contributor.authorSilva, Eloiza Helena Tajara da
dc.contributor.authorLouro, Iuri Drummond
dc.contributor.authorSilva-Conforti, A. M. A
dc.date.accessioned2021-02-19T10:12:25Z
dc.date.available2021-02-19T10:12:25Z
dc.date.issued2015-11-24
dc.description.resumoFive-year survival rates for oral squamous cell carcinoma (OSCC) are 30% and the mortality rate is 50%. Immunohistochemistry panels are used to evaluate proliferation, vascularization, apoptosis, HPV infection, and keratin expression, which are important markers of malignant progression. Keratins are a family of intermediate filaments predominantly expressed in epithelial cells and have an essential role in mechanical support and cytoskeleton formation, which is essential for the structural integrity and stability of the cell. In this study, we analyzed the expressions of keratins 17 and 19 (K17 and K19) by immunohistochemistry in tumoral and non-tumoral tissues from patients with OSCC. The results show that expression of these keratins is higher in tumor tissues compared to non-tumor tissues. Positive K17 expression correlates with lymph node metastasis and multivariate analysis confirmed this relationship, revealing a 6-fold increase in lymph node metastasis when K17 is expressed. We observed a correlation between K17 expression with disease-free survival and disease-specific death in patients who received surgery and radiotherapy. Multivariate analysis revealed that low expression of K17 was an independent marker for early disease relapse and disease-specific death in patients treated with surgery and radiotherapy, with an approximately 4-fold increased risk when compared to high K17 expression. Our results suggest a potential role for K17 and K19 expression profiles as tumor prognostic markers in OSCC patientspt_BR
dc.identifier.citationKATHER, B. A. C.; PETERLE, G. T.; SANTOS, Marcelo dos; AGOSTINI, L. P.; MAIA, L. L.; STUR, E.; SILVA, C. V. M.; MENDES, S .O.; ALMANCA, C. C. J.; FREITAS, F. V.; BORCOI, A. R.; ARCHANJO, A. B.; MERCANTE, A. M. C.; NUNES, F. D.; CARVALHO, M. B.; TAJARA, E. H.; LOURO, I. D.; SILVA, A. M. A. Keratins 17 and 19 expression as prognostic markers in oral squamous cell carcinoma. Genetics and Molecular Research, [s. l.], v. 14, n. 4, p. 15123-15132, 2015. Disponível em:https://www.geneticsmr.org/articles/keratins-17-and-19-expression-as-prognostic-markers-in-oral-squamous-cell-carcinoma.pdf. Acesso em: 07 jul. 2020. http://dx.doi.org/10.4238/2015.November.24.21pt_BR
dc.identifier.doi10.4238/2015.November.24.21
dc.identifier.issn1676-5680 (print)
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/31558
dc.languageenpt_BR
dc.publisherFundação de Pesquisas de Ribeirão Pretopt_BR
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/br/*
dc.subjectKeratin 17pt_BR
dc.subjectKeratin 19pt_BR
dc.subjectOral squamous cell carcinomapt_BR
dc.subjectPrognostic markerpt_BR
dc.titleKeratins 17 and 19 expression as prognostic markers in oral squamous cell carcinomapt_BR
dc.typearticlept_BR

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