PAI-1 expression in intratumoral inflammatory infiltrate contributes to lymph node metastasis in oral cancer: a cross-sectional study

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dc.contributor.authorOliveira, Mayara Mota de
dc.contributor.authorPeterle, Gabriela Tonini
dc.contributor.authorCouto, Cinthia Vidal Monteiro da Silva
dc.contributor.authorMaia, Lucas de Lima
dc.contributor.authorKühl, Andre
dc.contributor.authorSantos, Joaquim Gasparini dos
dc.contributor.authorMoysés, Raquel Ajub
dc.contributor.authorTrivilin, Leonardo Oliveira
dc.contributor.authorBorçoi, Aline Ribeiro
dc.contributor.authorArchanjo, Anderson Barros
dc.contributor.authorAssis, Arícia Leone Evangelista Monteiro de
dc.contributor.authorNunes, Fábio Daumas
dc.contributor.authorSantos, Marcelo dos
dc.contributor.authorSilva, Adriana Madeira Álvares da
dc.date.accessioned2022-02-01T15:49:43Z
dc.date.available2022-02-01T15:49:43Z
dc.date.issued2021-04-15
dc.description.resumoIntroduction: Immune cells contribute with mediators in the protein expression profile of the tumor microenvi ronment. Levels of plasminogen activator inhibitor-1 (PAI-1) are elevated in non-malignant inflammatory con ditions; however, the association between PAI-1 expression and inflammation remains uncertain in oral squamous cell carcinoma (OSCC). This study aimed to investigate PAI-1 expression in mononuclear inflammatory cell infiltrate in OSCC and its role as a prognostic marker. Methods: Samples were collected from patients with OSCC, treated surgically, and followed for 24 months after the procedure. Thirty-nine tumoral tissue were analyzed using immunohistochemistry. Correlation between protein expression, clinicopathological parameters, and the prognosis was investigated. Results: Positive PAI-1 expression in mononuclear inflammatory cell infiltrate was significantly associated with lymph node status (p = 0.009) and with the cytoplasmic expression of vascular endothelial growth factor A (VEGFA) (p = 0.028). Multivariate analysis revealed weak PAI-1 expression as an independent marker for lymph node metastases, with approximately 8-fold increased risk compared to strong expression (OR = 8.60; CI =1.54–48.08; p = 0.014). Conclusion: Our results suggest that the strong PAI-1 expression in intratumoral inflammatory infiltrate is an indicator of a better prognosis for patients diagnosed with oral squamous cell carcinoma.pt_BR
dc.identifier.citationOLIVEIRA, Mayara Mota de et al. PAI-1 expression in intratumoral inflammatory infiltrate contributes to lymph node metastasis in oral cancer: a cross-sectional study. Annals of Medicine and Surgery, [s. l.], v. 65, p. 1-6, 15 abr. 2021. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167432/. Acesso em: 28 jan. 2022. http://doi.org/10.1016/j.amsu.2021.102303pt_BR
dc.identifier.doi10.1016/j.amsu.2021.102303
dc.identifier.issn2049-0801 (online)
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/45745
dc.languageenpt_BR
dc.publisherElsevierpt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectPAI-1pt_BR
dc.subjectOral squamous cell carcinomapt_BR
dc.subjectLymph nodept_BR
dc.subjectPrognostic markerpt_BR
dc.titlePAI-1 expression in intratumoral inflammatory infiltrate contributes to lymph node metastasis in oral cancer: a cross-sectional studypt_BR
dc.typearticlept_BR

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