Avaliação da perda óssea e atividade antiinflamatória da azilzartana em modelo de doença periodontal

Abstract

Aims: The aim of this study was to evaluate the effects of azilsartan (AZT) on bone loss, inflammation. Materials and Methods: Male Wistar albino rats were randomly divided into 5 groups of 10 rats each: (1) nonligated, water; (2) ligated, water; (3) ligated, 1 mg/kg AZT; (4) ligated, 5 mg/kg AZT; and (5) ligated, 10 mg/kg AZT. All groups were treated with saline or AZT for 10 days. Levels of IL-1β, IL-10, TNF-α, myeloperoxidase (MPO), and glutathione (GSH) were determined by ELISA. Results: Treatment with 5 mg/kg AZT resulted in reduced MPO (p <0.05) and IL-1β (p <0.05), increased levels of IL-10 (p <0.05). Conclusions: These findings reveal that AZT increases anti-inflammatory cytokines and GSH and decreases bone loss in ligature-induced periodontitis in rats.