Antimicrobial effects of photodynamic therapy with Fotoenticine on Streptococcus mutans isolated from dental caries

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dc.contributor.authorTerra-Garcia, Maíra
dc.contributor.authorSouza, Cheyenne Marçal de
dc.contributor.authorGonçalves, Nathalia Maria Ferreira
dc.contributor.authorPereira, André Henrique Correia
dc.contributor.authorBarros, Patrícia Pimentel de
dc.contributor.authorBorges, Alessandra Bühler
dc.contributor.authorMiyakawa, Walter
dc.contributor.authorStrixino, Juliana Ferreira
dc.contributor.authorJunqueira, Juliana Campos
dc.contributor.authorIDhttps://orcid.org/0000-0003-4885-2811pt_BR
dc.date.accessioned2022-04-01T13:35:14Z
dc.date.available2022-04-01T13:35:14Z
dc.date.issued2021-06
dc.description.resumoPhotodynamic therapy (PDT) is a promising strategy to control cariogenic pathogens, such as Streptococcus mutans. Seeking to reach the total bacterial elimination from dental surfaces, novel photosensitizers have been investigated, such as Fotoenticine (FTC) derived from chlorin e6. The objective of this study was to investigate the photodynamic effects of FTC against several clinical strains of S. mutans. Clinical isolates were obtained from patients with active carious lesions, identified by molecular analysis and subjected to PDT using laser irradiation (660 nm and 39.5 J/cm2) in planktonic and biofilm stages. We identified 11 S. mutans strains from cervical, occlusal and proximal caries. PDT mediated by FTC has totally eliminated the S. mutans cells in planktonic growth for all analyzed strains. In biofilms, PDT with FTC reached statistically significant reductions compared with the non-treated control group, at 5.4, 5.5 and 6.5 Log10 (CFU/mL), respectively, for the strains from proximal, occlusal and cervical caries. The scanning electron microscopy evaluations confirmed that PDT mediated by FTC was able to disaggregate and kill the S. mutans cells adhered to enamel surface, suggesting its potential to disinfect the dental tissuespt_BR
dc.identifier.citationTERRA-GARCIA, Maíra et al. Antimicrobial effects of photodynamic therapy with Fotoenticine on Streptococcus mutans isolated from dental caries. Photodiagnosis and Photodynamic Therapy, [s. l.], v. 34, p. 1-8, jun. 2021. Disponível em: https://www.sciencedirect.com/science/article/pii/S1572100021001290?via%3Dihub. Acesso em: 29 mar. 2022. http://dx.doi.org/10.1016/j.pdpdt.2021.102303pt_BR
dc.identifier.doi10.1016/j.pdpdt.2021.102303
dc.identifier.issn1572-1000
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/46764
dc.languageenpt_BR
dc.publisherElsevierpt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectPhotodynamic therapypt_BR
dc.subjectStreptococcus mutanspt_BR
dc.subjectDental cariespt_BR
dc.subjectFotoenticinept_BR
dc.titleAntimicrobial effects of photodynamic therapy with Fotoenticine on Streptococcus mutans isolated from dental cariespt_BR
dc.typearticlept_BR

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