Characterization of desvenlafaxine and compatibility studies with pharmaceutical excipients by DSC, TG and FTIR

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dc.contributor.advisorGomes, Ana Paula Barreto
dc.contributor.advisorLatteshttps://lattes.cnpq.br/1689823596741892pt_BR
dc.contributor.authorSantos, Ana Neri Nascimento dos
dc.contributor.authorIDhttps://orcid.org/0009-0003-4944-5449pt_BR
dc.contributor.authorLatteshttp://lattes.cnpq.br/5264325086735174pt_BR
dc.contributor.referees1Aragão, Cícero Flávio Soares de
dc.contributor.referees2Porto, Dayanne Lopes
dc.date.accessioned2023-12-13T20:23:00Z
dc.date.available2023-12-13T20:23:00Z
dc.date.issued2023-11-30
dc.description.resumoThe Desvenlafaxine (DES) is a third-generation antidepressant indicated for the treatment of Major Depressive Disorder (MDD). Like any medication during development, a preformulation study is necessary, involving the evaluation of the physicochemical properties of the active pharmaceutical ingredient (API) to generate information for the development of a pharmaceutical formulation. Considering the absence of literature studies on the characterization of DES, we propose to undertake this work, focusing on thermal characterization and compatibility studies. The analytical techniques employed include Differential Scanning Calorimetry (DSC), Thermogravimetry (TG), and Fourier Transform Infrared Spectroscopy (FTIR). Desvenlafaxine was assessed with pharmaceutical excipients: lactose, mannitol, starch, and sodium carboxymethylcellulose. This study aims to identify potential incompatibilities in the binary mixture that could lead to a reduction in therapeutic effects or alterations in pharmacokinetics. The thermal analysis techniques (DSC and TG) indicated compatibility between desvenlafaxine and the excipients: starch, mannitol, and sodium carboxymethylcellulose. However, the analysis using FTIR revealed that there aren’t interaction between desvenlafaxine and lactose. Thus, based on the results, it is possible to propose a more stable, secure, and effective formulation.pt_BR
dc.identifier.citationSANTOS, Ana Neri Nascimentos dos. Characterization of desvenlafaxine and compatibility studies with pharmaceutical excipients by DSC, TG and FTIR. Orientadora: Ana Paula Barreto Gomes. 2023. 24 f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2023.pt_BR
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/55892
dc.languageenpt_BR
dc.publisherUniversidade Federal do Rio Grande do Nortept_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentDepartamento de Farmáciapt_BR
dc.publisher.initialsUFRNpt_BR
dc.publisher.programFarmáciapt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectDesvenlafaxinept_BR
dc.subjectDSCpt_BR
dc.subjectTGpt_BR
dc.subjectFTIRpt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDE::FARMACIA::ANALISE E CONTROLE E MEDICAMENTOSpt_BR
dc.titleCharacterization of desvenlafaxine and compatibility studies with pharmaceutical excipients by DSC, TG and FTIRpt_BR
dc.typebachelorThesispt_BR

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