Estudo da porosidade de arcabouços de Ti-Nb2O5-Sn para aplicação biomédica

Abstract

The scaffolds are porous structures three-dimensional, where tissue cells are placed together with growth factors to facilitate and / or allow tissue growth. The growth of cells in porous supports three-dimensional (scaffolds) has become increasingly active in tissue engineering. It guides cell growth, synthesizes an extracellular matrix and other biological molecules and facilitates the formation of functional tissues and organs. To fulfill this function, the scaffold must possess properties such as biocompatibility, high porosity, pore size suitable to allow tissue growth and large surface area to allow for vascularization. In this paper, scaffolds of Ti alloys were produced by compacting and sintering process of powders of Ti, Sn and Nb2O5 in order to obtain parts with size and pore distribution different and interconnectivity. The samples were characterized by optical microscopy, scanning electron microscopy and image analysis. During these characterizations, the samples were divided into two regions, edge and core. Absorption tests also were conducted in the samples. The samples showed different porosities at the edge (30.54% to 66.83%) and core (7.44% to 58.80%). The pore sizes found in the samples ranged from less than 10µm and above 150 µm. In this work, the scaffolds were obtained with porosity variations between edge and core. The samples showed more porous surface than the core. Moreover, we managed to obtain pore sizes according to the literature that provides the fibrovascular growth, formation of osteoid and growth bone