Trypanosoma cruzi III causing the indeterminate form of Chagas disease in a semi-arid region of Brazil

Martins, Kiev; Andrade, Cléber de Mesquita; Barbosa-Silva, Andressa Noronha; Nascimento, Gerson Barbosa do; Chiari, Egler; Galvão, Lúcia Maria da Cunha; Câmara, Antonia Cláudia Jácome da

Trypanosoma cruzi III causing the indeterminate form of Chagas disease in a semi-arid region of Brazil

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dc.contributor.author	Martins, Kiev
dc.contributor.author	Andrade, Cléber de Mesquita
dc.contributor.author	Barbosa-Silva, Andressa Noronha
dc.contributor.author	Nascimento, Gerson Barbosa do
dc.contributor.author	Chiari, Egler
dc.contributor.author	Galvão, Lúcia Maria da Cunha
dc.contributor.author	Câmara, Antonia Cláudia Jácome da
dc.date.accessioned	2020-12-22T11:12:48Z
dc.date.available	2020-12-22T11:12:48Z
dc.date.issued	2015-08
dc.description.resumo	Objective: Trypanosoma cruzi is subdivided into six discrete typing units (DTUs), TcI–TcVI. The precise identification of each can contribute to tracking wild DTUs that invade the domiciliary environment. Methods: Twenty T. cruzi stocks isolated from 16 chagasic patients, two Panstrongylus lutzi, one Galea spixii, and one Euphractus sexcinctus, from different localities in the State of Rio Grande do Norte, Brazil, were characterized by genotyping the 30 region of the 24Sa rRNA gene, the mitochondrial cytochrome oxidase subunit 2 gene, and the spliced leader intergenic region. Results: TcIII was identified in 18.7% (3/16) of patients from different municipalities, as well as in P. lutzi, G. spixii, and E. sexcinctus, indicating the connection between the sylvatic and domestic cycles in this Brazilian semi-arid region. TcI and TcII were also detected, in 37.5% (6/16) and 43.8% (7/16) of patients, respectively. These DTUs were associated with cardiac, digestive, and indeterminate clinical forms, while TcIII was identified only in patients with the indeterminate form. Conclusions: The occurrence of these DTUs reveals important phylogenetic diversity in T. cruzi isolates from humans. TcIII is reported for the first time in northeastern Brazil. These findings appear to indicate an overlap between the sylvatic and domestic transmission cycles of the parasite in this region.	pt_BR
dc.identifier.citation	MARTINS, Kiev; ANDRADE, Cléber de Mesquita; BARBOSA-SILVA, Andressa Noronha; NASCIMENTO, Gerson Barbosa do; CHIARI, Egler; GALVÃO, Lúcia Maria da Cunha; CÂMARA, Antonia Cláudia Jácome da. Trypanosoma cruzi III causing the indeterminate form of Chagas disease in a semi-arid region of Brazil. International Journal Of Infectious Diseases, [s. l.], v. 39, p. 68-75, out. 2015. Elsevier BV. http://dx.doi.org/10.1016/j.ijid.2015.08.012. Disponível em: https://www.ijidonline.com/article/S1201-9712(15)00207-6/fulltext. Acesso em: 09 nov. 2020.	pt_BR
dc.identifier.issn	1201-9712 (print)
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31097
dc.language	en	pt_BR
dc.publisher	Elsevier	pt_BR
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/br/	*
dc.subject	Trypanosoma cruzi	pt_BR
dc.subject	Discrete typing units	pt_BR
dc.subject	Chronic chagasic patients	pt_BR
dc.subject	Clinical forms	pt_BR
dc.subject	Genetic diversity	pt_BR
dc.title	Trypanosoma cruzi III causing the indeterminate form of Chagas disease in a semi-arid region of Brazil	pt_BR
dc.type	article	pt_BR