Please use this identifier to cite or link to this item: https://repositorio.ufrn.br/jspui/handle/123456789/25921
Title: PERK, mTORC1 and eEF2 interplay during long term potentiation: an editorial for 'Genetic removal of eIF2a kinase PERK in mice enables hippocampal L-LTP independent of mTORC1 activity' on page 133
Authors: Bevilaqua, Lia R. M.
Cammarota, Martín
Keywords: long-term memory;hippocampus
Issue Date: Jul-2018
Citation: BEVILAQUA, L.R.M.; CAMMAROTA, M. PERK, mTORC1 and eEF2 interplay during long term potentiation: an editorial for 'Genetic removal of eIF2a kinase PERK in mice enables hippocampal L-LTP independent of mTORC1 activity' on page 133. J Neurochem., v. 146, n. 2, p.119-121, jul/2018.
Portuguese Abstract: This Editorial highlights a study by Zimmermann and coworkers in the current issue of Journal of Neurochemistry. The authors' link suppression of PKR-like endoplasmatic reticulum kinase (PERK) activity to eukaryotic elongation factor 2 (eEF2) dephosphorylation and mTORC1-independent high-frequency stimulation (HFS)-induced long-term potentiation (LTP) in acute hippocampal slices from PERK forebrain conditional knockout mice. The results suggest that functional interaction between the signaling pathways controlling different phases of the mRNA translation process is necessary for long-term plasticity in the hippocampus.
URI: https://repositorio.ufrn.br/jspui/handle/123456789/25921
Appears in Collections:ICe - Artigos publicados em periódicos

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