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Title: Hippocampal and cortical communication around micro-arousals in slow-wave sleep
Authors: Lima, Gustavo Zampier dos Santos
Lobão-Soares, Bruno
Corso, Gilberto
Belchior, Hindiael Aeraf
Lopes, Sergio Roberto Lopes
Prado, Thiago de Lima
Nascimento, George Carlos do
Araújo, John Fontenele
Ivanov, Plamen Ch.
Keywords: Neural circuits;Neurophysiology
Issue Date: 10-Apr-2019
Publisher: Nature Publishing Group
Citation: LIMA, Gustavo Zampier dos Santos; LOBAO-SOARES, Bruno; CORSO, Gilberto; BELCHIOR, Hindiael; LOPES, Sergio Roberto; PRADO, Thiago de Lima; NASCIMENTO, George; FRANÇA, Arthur Cavalcanti de; FONTENELE-ARAÚJO, John; IVANOV, Plamen Ch.. Hippocampal and cortical communication around micro-arousals in slow-wave sleep. Scientific Reports, [S.L.], v. 9, n. 1, p. 5876-5876, 10 abr. 2019. Disponível em: Acesso em: 20 nov. 2020.
Portuguese Abstract: Sleep plays a crucial role in the regulation of body homeostasis and rhythmicity in mammals. Recently, a specific component of the sleep structure has been proposed as part of its homeostatic mechanism, named micro-arousal. Here, we studied the unique progression of the dynamic behavior of cortical and hippocampal local field potentials (LFPs) during slow-wave sleep-related to motor-bursts (micro-arousals) in mice. Our main results comprised: (i) an abrupt drop in hippocampal LFP amplitude preceding micro-arousals which persisted until the end of motor-bursts (we defined as t interval, around 4s) and a similar, but delayed amplitude reduction in cortical (S1/M1) LFP activity occurring at micro-arousal onset; (ii) two abrupt frequency jumps in hippocampal LFP activity: from Theta (6–12 Hz) to Delta (2–4 Hz), also t seconds before the micro-arousal onset, and followed by another frequency jump from Delta to Theta range (5–7 Hz), now occurring at micro-arousal onset; (iii) a pattern of cortico-hippocampal frequency communication precedes micro-arousals: the analysis between hippocampal and cortical LFP fluctuations reveal high coherence during τ interval in a broader frequency band (2–12 Hz), while at a lower frequency band (0.5–2 Hz) the coherence reaches its maximum after the onset of micro-arousals. In conclusion, these novel findings indicate that oscillatory dynamics pattern of cortical and hippocampal LFPs preceding micro-arousals could be part of the regulatory processes in sleep architecture
ISSN: 1678-765X
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