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Title: Spatial clustering of orientation preference in primary visual cortex of the large rodent agouti
Authors: Ferreiro, Dardo Nahuel
Conde Ocazionez, Sergio Andrés
Patriota, João Henrique Nascimento
Souza, Luã Carlos de
Oliveira, Moacir Franco de
Wolf, Fred
Schmidt, Kerstin Erika
Keywords: Primary visual cortex (V1);Agouti;Cuniculidae;Optical imaging;Orientation, spatial;Sensory Neuroscience
Issue Date: 30-Nov-2020
Publisher: Elsevier
Citation: FERREIRO, Dardo N.; CONDE-OCAZIONEZ, Sergio A.; PATRIOTA, João H.N.; SOUZA, Luã C.; OLIVEIRA, Moacir F.; WOLF, Fred; SCHMIDT, Kerstin E. Spatial clustering of orientation preference in primary visual cortex of the large rodent agouti. Iscience, [S. l.], v. 24, n. 1, p. 101882, jan. 2021. Doi: Disponível em: Acesso em: 14 dez. 2020.
Portuguese Abstract: All rodents investigated so far possess orientation-selective neurons in the primary visual cortex (V1) but – in contrast to carnivores and primates – no evidence of periodic maps with pinwheel-like structures. Theoretical studies debating whether phylogeny or universal principles determine development of pinwheels point to V1 size as a critical constraint. Thus, we set out to study maps of agouti, a big diurnal rodent with a V1 size comparable to cats'. In electrophysiology, we detected interspersed orientation and direction-selective neurons with a bias for horizontal contours, corroborated by homogeneous activation in optical imaging. Compatible with spatial clustering at short distance, nearby neurons tended to exhibit similar orientation preference. Our results argue against V1 size as a key parameter in determining the presence of periodic orientation maps. They are consistent with a phylogenetic influence on the map layout and development, potentially reflecting distinct retinal traits or interspecies differences in cortical circuitry
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