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Title: In Vivo evaluation of the antioxidant activity and protective action of the seaweed Gracilaria birdiae
Authors: Barros-Gomes, Joanna Angelis Costa
Nascimento, Daiany Laise Araújo
Silveira, Ana Cristina Rodrigues
Silva, Rayanne Kelly
Gomes, Dayane Lopes
Melo, Karoline Rachel Teodosio
Almeida-Lima, Jailma
Câmara, Rafael Barros Gomes da
Silva, Naisandra Bezerra
Rocha, Hugo Alexandre de Oliveira
Keywords: Animals;Antioxidants, pharmacology;Gracilaria birdiae
Issue Date: 1-Aug-2018
Publisher: Hindawi
Citation: BARROS-GOMES, Joanna Angelis Costa; NASCIMENTO, Daiany Laise Araújo; SILVEIRA, Ana Cristina Rodrigues; SILVA, Rayanne Kelly; GOMES, Dayane Lopes; MELO, Karoline Rachel Teodosio; ALMEIDA-LIMA, Jailma; CAMARA, Rafael Barros Gomes; SILVA, Naisandra Bezerra; ROCHA, Hugo Alexandre de Oliveira. In Vivo evaluation of the antioxidant activity and protective action of the seaweed Gracilaria birdiae. Oxidative Medicine And Cellular Longevity, [s. l.], v. 2018, p. 1-12, 1 ago. 2018. Hindawi Limited. Disponível em: Acesso em: 03 ago. 2020.
Portuguese Abstract: The red seaweed Gracilaria birdiae (GB) is farmed and used as food in northeast Brazil. However, the economic potential of this seaweed has been explored little. To enable direct consumption and/or product diversification from GB, it is necessary to evaluate its effect in vivo. In this study, the food of mice was improved with the addition of GB. After 21 days, the consumption of seaweed reduced the weight gain and blood glucose levels in mice. In addition, it increased the trolox equivalent antioxidant capacity and glutathione reductase and catalase levels compared to those of the control group. In addition, some mice also received carbon tetrachloride (CCl4). In this case, histological, enzymatic, and antioxidant tests showed that the seaweed could protect animals from damage caused by this toxic agent. In addition, GB aqueous extract (AE) inhibited 50% of 3T3-L1 cell differentiation into adipocytes, whereas GB ethanolic extract was not effective. AE is composed mainly of sulfated polysaccharides. The results of the present study indicate that the alga GB protected the mice from CCl4-induced damage, indicating that the seaweed exhibits protective action in vivo. In addition, GB decreased the animal weight gain, which was mainly due to the action of the sulfated polysaccharides synthesized by this seaweed
ISSN: 1942-0994 (online)
1942-0900 (print)
Appears in Collections:CB - DBQ - Artigos publicados em periódicos
CB - DMOR - Artigos publicados em periódicos
EMCM - Artigos publicados em periódicos

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