1. Universidade Federal do Rio Grande do Norte
2. Escola Multicampi de Ciências Médicas do Rio Grande do Norte
3. EMCM - Artigos publicados em periódicos

Title:	Diet-Induced weight loss reduces DNA damage and cardiometabolic risk factors in overweight/obese women with polycystic ovary syndrome
Authors:	Soares, Nayara Pereira Santos, Ana Celly Souza dos Costa, Eduardo Caldas Azevedo, George Dantas de Damasceno, Débora Cristina Fayh, Ana Paula Trussardi Lemos, Telma Maria Araujo Moura
Keywords:	Diet;DNA damage;Cardiometabolic risk factors;Overweight;Obesity;Polycystic ovary syndrome
Issue Date:	14-Apr-2016
Publisher:	Karger Publishers
Citation:	SOARES, Nayara Pereira; SANTOS, Ana Celly Souza dos; COSTA, Eduardo Caldas; AZEVEDO, George Dantas de; DAMASCENO, Débora Cristina; FAYH, Ana Paula Trussardi; LEMOS, Telma Maria Araújo Moura. Diet-Induced weight loss reduces DNA damage and cardiometabolic risk factors in overweight/obese women with polycystic ovary syndrome. Annals Of Nutrition And Metabolism, [s. l.], v. 68, n. 3, p. 220-227, 2016. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27073909/. Acesso em: 18 fev. 2021. http://dx.doi.org/10.1159/000444130
Portuguese Abstract:	Aims: we aimed to investigate the impact of following a diet to induce weight loss (500 kcal deficit per day) over DNA damage and cardiometabolic risk factors in women with overweight/obesity diagnosed with polycystic ovary syndrome (PCOS). Methods: a study was conducted in Natal, RN, Brazil selecting overweight/obese (body mass index ≥25 and <39 kg/m2) women (18-35 years). The levels of DNA damage were assessed by a single cell gel electrophoresis. Repeated 24 h dietary recall questionnaires, anthropometry, biochemical profile and sex hormones were collected at baseline and after 12 weeks of intervention. Results: Women exhibiting a decrease in the markers of DNA damage: tail intensity (24.35 ± 5.86 - pre diet vs. 17.15 ± 5.04 - post-diet; p < 0.001) and tail moment (20.47 ± 7.85 - pre diet vs. 14.13 ± 6.29 - post-diet; p < 0.002). Reduction of calorie intake, weight loss, decreased sexual hormone and cardiometabolic markers such as insulin, homeostasis model assessment of insulin resistance and low-density lipoprotein cholesterol were verified In the multivariate regression analysis, quantitative insulin sensitivity check index and progesterone were responsible for the variation markers in DNA damage before the diet, losing its influence upon diet. Conclusion: DNA damage and the impact of cardiometabolic risk factors decreased after the intervention in women with PCOS, indicating the relevance of a nutritional approach in this group of patients
URI:	https://repositorio.ufrn.br/handle/123456789/31563
ISSN:	0250-6807 1421-9697 10.1159/000444130
Appears in Collections:	CB - DMOR - Artigos publicados em periódicos CCS - DACT- Artigos publicados em periódicos CCS - DEDFIS - Artigos Publicados em Periódicos CCS - DNUT - Artigos publicados em periódicos EMCM - Artigos publicados em periódicos

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