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Título: | Phenolic profile and antioxidant activity from peels and seeds of melon (Cucumis melo L. var. reticulatus) and their antiproliferative effect in cancer cells |
Autor(es): | Santos, Everaldo Silvino dos Rolim, Priscilla Moura Fidelis, Gabriel Pereira Padilha, Carlos Eduardo de Araújo Rocha, Hugo Alexandre de Oliveira Macedo, Gorete Ribeiro de |
Palavras-chave: | Melon residues;Antioxidant activity;Cancer cells;Free radical scavenging activity;Metal chelator;Cytotoxicity |
Data do documento: | 2018 |
Editor: | Associação Brasileira de Divulgação Científica |
Referência: | ROLIM, P. M. ; FIDELIS, G. ; PADILHA, C. E. ; SANTOS, E. S. ; Rocha, H. A. O. ; Macedo, Gorete R. . Phenolic profile and antioxidant activity from peels and seeds of melon (Cucumis melo L. var. reticulatus) and their antiproliferative effect in cancer cells. Brazilian Journal of Medical and Biological Research (on line), v. 51, p. 1-14, 2018. Disponível em https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000400607&tlng=en. Acesso em: 13 abr. 2021. https://doi.org/10.1590/1414-431X20176069. |
Resumo: | Melon (Cucumis melo L.) has high economic value and in recent years, its production has increased; however, part of the fruit is wasted. Usually, inedible parts such as peel and seeds are discarded during processing and consumption. Extracts of melon residues were prepared and their phenolic compounds, antioxidants and antiproliferative activities were evaluated. Total phenolic compounds were found in hydroethanolic, hydromethanolic, and aqueous extracts, especially for melon peel (1.016 mg gallic acid equivalent/100 g). Flavonoids total content found for melon peel aqueous extract was 262 mg of catechin equivalent (CA)/ 100 g. In all extracts of melon peel significant amounts of gallic acid, catechin, and eugenol were found. For total antioxidant capacity, reported as ascorbic acid equivalent, the hydroethanolic and hydromethanolic extracts in peels and hydromethanolic in seeds were 89, 74, and 83 mg/g, respectively. Different extracts of melon showed iron and copper ions chelating activity at different concentrations, especially melon peel aqueous extract, reaching values of 61% for iron and 84% for copper. The hydroethanolic extract of melon peel presented a significant ability for hydroxyl radicals scavenging (68%). To assess the antiproliferative potential in human cancer cell lines, such as kidney carcinoma, colorectal carcinoma, cervical adenocarcinoma and cervical carcinoma, MTT assay was performed. The proliferation was inhibited by 20–85% at extracts concentrations of 0.1–1.0 mg/mL in all cancer cell lines. The results suggest that melon residues extracts display a high antioxidant activity in in vitro assays and have effective biological activity against the growth of human tumor cells. |
URI: | https://repositorio.ufrn.br/handle/123456789/32584 |
ISSN: | 0100-879X 1414-431X |
Aparece nas coleções: | CB - DBQ - Artigos publicados em periódicos CCS - DNUT - Artigos publicados em periódicos CT - DEQ - Artigos publicados em periódicos |
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PhenolicProfileAndAntioxidant_Santos_2018.pdf | 3,58 MB | Adobe PDF | Visualizar/Abrir |
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