Please use this identifier to cite or link to this item:
Title: Phenolic profile and antioxidant activity from peels and seeds of melon (Cucumis melo L. var. reticulatus) and their antiproliferative effect in cancer cells
Authors: Santos, Everaldo Silvino dos
Rolim, Priscilla Moura
Fidelis, Gabriel Pereira
Padilha, Carlos Eduardo de Araújo
Rocha, Hugo Alexandre de Oliveira
Macedo, Gorete Ribeiro de
Keywords: Melon residues;Antioxidant activity;Cancer cells;Free radical scavenging activity;Metal chelator;Cytotoxicity
Issue Date: 2018
Publisher: Associação Brasileira de Divulgação Científica
Citation: ROLIM, P. M. ; FIDELIS, G. ; PADILHA, C. E. ; SANTOS, E. S. ; Rocha, H. A. O. ; Macedo, Gorete R. . Phenolic profile and antioxidant activity from peels and seeds of melon (Cucumis melo L. var. reticulatus) and their antiproliferative effect in cancer cells. Brazilian Journal of Medical and Biological Research (on line), v. 51, p. 1-14, 2018. Disponível em Acesso em: 13 abr. 2021.
Portuguese Abstract: Melon (Cucumis melo L.) has high economic value and in recent years, its production has increased; however, part of the fruit is wasted. Usually, inedible parts such as peel and seeds are discarded during processing and consumption. Extracts of melon residues were prepared and their phenolic compounds, antioxidants and antiproliferative activities were evaluated. Total phenolic compounds were found in hydroethanolic, hydromethanolic, and aqueous extracts, especially for melon peel (1.016 mg gallic acid equivalent/100 g). Flavonoids total content found for melon peel aqueous extract was 262 mg of catechin equivalent (CA)/ 100 g. In all extracts of melon peel significant amounts of gallic acid, catechin, and eugenol were found. For total antioxidant capacity, reported as ascorbic acid equivalent, the hydroethanolic and hydromethanolic extracts in peels and hydromethanolic in seeds were 89, 74, and 83 mg/g, respectively. Different extracts of melon showed iron and copper ions chelating activity at different concentrations, especially melon peel aqueous extract, reaching values of 61% for iron and 84% for copper. The hydroethanolic extract of melon peel presented a significant ability for hydroxyl radicals scavenging (68%). To assess the antiproliferative potential in human cancer cell lines, such as kidney carcinoma, colorectal carcinoma, cervical adenocarcinoma and cervical carcinoma, MTT assay was performed. The proliferation was inhibited by 20–85% at extracts concentrations of 0.1–1.0 mg/mL in all cancer cell lines. The results suggest that melon residues extracts display a high antioxidant activity in in vitro assays and have effective biological activity against the growth of human tumor cells.
ISSN: 0100-879X
Appears in Collections:CB - DBQ - Artigos publicados em periódicos
CCS - DNUT - Artigos publicados em periódicos
CT - DEQ - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
PhenolicProfileAndAntioxidant_Santos_2018.pdf3.58 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons