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Title: Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation
Authors: Almeida Filho, Daniel Gomes de
Koike, Bruna Del Vechio
Billwiller, Francesca
Farias, Kelly Soares
Sales, Igor Rafael Praxedes de
Luppi, Pierre-Hervé
Ribeiro, Sidarta Tollendal Gomes
Queiroz, Claudio Marcos Teixeira de
Keywords: Hippocampus;Theta rhythm;Sleep, REM;Spatial learning;Gyrus cinguli
Issue Date: 22-Jun-2021
Publisher: Springer Science and Business Media LLC
Citation: ALMEIDA-FILHO, Daniel Gomes de; KOIKE, Bruna del Vechio; BILLWILLER, Francesca; FARIAS, Kelly Soares; SALES, Igor Rafael Praxedes de; LUPPI, Pierre-Hervé; RIBEIRO, Sidarta; QUEIROZ, Claudio Marcos. Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation. Scientific Reports, [S. l.], v. 11, n. 1, p. 13078. jun. 2021. Doi: Disponível em: Acesso em: 24 jun. 2021.
Portuguese Abstract: Hippocampal (HPC) theta oscillation during post-training rapid eye movement (REM) sleep supports spatial learning. Theta also modulates neuronal and oscillatory activity in the retrosplenial cortex (RSC) during REM sleep. To investigate the relevance of theta-driven interaction between these two regions to memory consolidation, we computed the Granger causality within theta range on electrophysiological data recorded in freely behaving rats during REM sleep, both before and after contextual fear conditioning. We found a training-induced modulation of causality between HPC and RSC that was correlated with memory retrieval 24 h later. Retrieval was proportional to the change in the relative influence RSC exerted upon HPC theta oscillation. Importantly, causality peaked during theta acceleration, in synchrony with phasic REM sleep. Altogether, these results support a role for phasic REM sleep in hippocampo-cortical memory consolidation and suggest that causality modulation between RSC and HPC during REM sleep plays a functional role in that phenomenon
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