1. Universidade Federal do Rio Grande do Norte
2. BDM - Biblioteca Digital de Monografias
3. Monografias de Graduação
4. CCS - TCC - Farmácia

Título:	Previous vitamin D status and total cholesterol are associated with SARS-CoV-2 infection
Autor(es):	Ribeiro, Heriks Gomes
Orientador:	Silbiger, Vivian Nogueira
Palavras-chave:	COVID-19;COVID-19;Cholecalciferol;Colecalciferol;Lipid Profile;Perfil Lipídico;SARS-CoV-2;SARS-CoV-2
Data do documento:	20-Ago-2021
Editor:	Universidade Federal do Rio Grande do Norte
Referência:	RIBEIRO, Heriks Gomes. Previous vitamin D status and total cholesterol are associated with SARS-CoV-2 infection. 2021. 24f. Trabalho de Conclusão de Curso (Graduação em Farmácia) – Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte, Natal, 2021.
Resumo:	Background and Aims: The relationship of vitamin D status and other biochemical parameters with the risk of SARS-CoV-2 infection remains inconclusive, especially in regions with high solar incidence. Therefore, we aimed to associate the 25-hydroxyvitamin D (25(OH)D) levels and lipid profile prior to the SARS-CoV-2 tests in a population from a sunny region in Brazil (5° S, 35° W). Methods and Results: This is a retrospective cohort study which enrolled 1634 patients tested for SARS-CoV-2 of a private medical laboratory with 25(OH)D level and lipid profile measured seven or more days before the date of the first SARS-CoV-2 RT-PCR test and were categorized according to 25(OH)D sufficiency (≥ 30 ng/ml) or insufficiency (< 30 ng/mL). Multiple logistic regression analyses were performed to assess risk factors associated with positive tests for SARS-CoV-2. Average serum 25(OH)D was 33.6 ng/mL. The vitamin D deficiency (< 20 ng/mL) reached only 2.6% of the participants. Multivariate analysis demonstrated that patients > 49 years old with insufficient 25(OH)D (< 30 ng/mL) presented increased odds to test positive for SARS-CoV-2 (OR: 2.02, 95%CI: 1.15 to 3.55, P = 0.015). The same is observed among those with Total Cholesterol > 190 mg/dL (OR: 1.90, 95%CI: 1.10 to 3.28, P = 0.020). Conclusions: Previous insufficient 25(OH)D (< 30 ng/mL) concentration and high total cholesterol were associated with SARS-CoV-2 infection among adults older than 49 years in the study population. Further studies should be conducted to confirm whether measurement of 25(OH)D and lipid profile could be useful to identify patients who are more susceptible to COVID-19.
URI:	https://repositorio.ufrn.br/handle/123456789/35710
Outros identificadores:	2016081700
Aparece nas coleções:	CCS - TCC - Farmácia

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