1. Universidade Federal do Rio Grande do Norte
2. Centro de Ciências da Saúde
3. DNUT - Departamento de Nutrição
4. CCS - DNUT - Artigos publicados em periódicos

Título:	Anti-TNF-α agent tamarind kunitz trypsin inhibitor improves lipid profile of Wistar rats presenting dyslipidemia and diet-induced obesity regardless of PPAR-γ induction
Autor(es):	Morais, Ana Heloneida de Araújo Carvalho, Fabiana Maria Coimbra de Lima, Vanessa Cristina Oliveira de Costa, Izael Souza Luz, Anna Beatriz Santana Ladd, Fernando Vagner Lobo Serquiz, Alexandre Coelho Bortolin, Raul Hernandes Silbiger, Vivian Nogueira Maciel, Bruna Leal Lima Santos, Elizeu Antunes dos
Palavras-chave:	Inflammation;tamarindus indica L.;triglycerides;VLDL
Data do documento:	2019
Editor:	Nutrients
Referência:	CARVALHO, Fabiana Maria Coimbra de. Anti-TNF-α agent tamarind kunitz trypsin inhibitor improves lipid profile of wistar rats presenting dyslipidemia and diet-induced obesity regardless of PPAR-γ induction. Nutrients, v. 11, n. 3, p. 512, 2019. Disponível em: https://www.mdpi.com/2072-6643/11/3/512. Acesso em: 5 jul. 2023
Resumo:	The increasing prevalence of obesity and, consequently, chronic inflammation and its complications has increased the search for new treatment methods. The effect of the purified tamarind seed trypsin inhibitor (TTIp) on metabolic alterations in Wistar rats with obesity and dyslipidemia was evaluated. Three groups of animals with obesity and dyslipidemia were formed, consuming a high glycemic index and glycemic load (HGLI) diet, for 10 days: Obese/HGLI diet; Obese/standard diet; Obese/HGLI diet + TTIp (730 µg/kg); and one eutrophic group of animals was fed a standard diet. Rats were evaluated daily for food intake and weight gain. On the 11th day, animals were anesthetized and sacrificed for blood and visceral adipose tissue collection. TTIp treated animals presented significantly lower food intake than the untreated group (p = 0.0065), TG (76.20 ± 18.73 mg/dL) and VLDL-C (15.24 ± 3.75 mg/dL). Plasma concentrations and TNF-α mRNA expression in visceral adipose tissue also decreased in obese animals treated with TTIp (p < 0.05 and p = 0.025, respectively) with a negative immunostaining. We conclude that TTIp presented anti-TNF-α activity and an improved lipid profile of Wistar rats with dyslipidemia and obesity induced by a high glycemic index and load diet regardless of PPAR-γ induction.
URI:	https://repositorio.ufrn.br/handle/123456789/54665
Aparece nas coleções:	CCS - DNUT - Artigos publicados em periódicos

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