1. Universidade Federal do Rio Grande do Norte
2. Centro de Ciências da Saúde
3. DNUT - Departamento de Nutrição
4. CCS - DNUT - Artigos publicados em periódicos

Título:	Adipocytes and intestinal epithelium dysfunctions linking obesity to inflammation induced by high glycemic index pellet-diet in wistar rats
Autor(es):	Maciel, Bruna Leal Lima Luz, Anna Beatriz Santana Figueredo, Júlia Braga dos Santos Salviano, Bianca Damásio Pereira Dantas Aguiar, Ana Júlia Felipe Camelo Pinheiro, Luiza Gabriella Soares Dantas Krause, Matheus Felipe Dantas Camillo, Christina da Silva Ladd, Fernando Vagner Lobo Bortolin, Raul Hernandes Silbiger, Vivian Nogueira Morais, Ana Heloneida de Araújo
Palavras-chave:	Adipocytes;Intestinal epithelium;Obesity;Pellet-diet
Data do documento:	Jun-2018
Editor:	Bioscience Reports
Referência:	LUZ, Anna Beatriz Santana; FIGUEREDO, Júlia Braga dos Santos; SALVIANO, Bianca Damásio Pereira Dantas; AGUIAR, Ana Júlia Felipe Camelo; PINHEIRO, Luiza Gabriella Soares Dantas; KRAUSE, Matheus Felipe Dantas; CAMILLO, Christina da Silva; LADD, Fernando Vagner Lobo; BORTOLIN, Raul Hernandes; SILBIGER, Vivian Nogueira; MACIEL, Bruna Leal Lima; MORAIS, Ana Heloneida de Araújo. Adipocytes and intestinal epithelium dysfunctions linking obesity to inflammation induced by high glycemic index pellet-diet in wistar rats. Bioscience Reports, [S.l.], v. 38, n. 3, p. 1-15, 27 jun. 2018. DOI: 10.1042/bsr20180304. Disponível em: https://portlandpress.com/bioscirep/article/38/3/BSR20180304/57532/Adipocytes-and-intestinal-epithelium-dysfunctions. Acesso em: 31 jan. 2024.
Resumo:	We investigated the inflammatory effect of a pellet-diet with high glycemic index and load (HGLI) on the histological organization of adipocytes, intestinal epithelium, and fat in liver and pancreas in adult male Wistar rats. Two groups (n=10) received for 17 weeks: (1) HGLI diet or (2) Standard diet (LabinaR ). Histological analyses of adipose tissue, jejunum, liver, and pancreas were performed. Stereology analysis, visceral adiposity index, gene expression, and immunohistochemistry of tumor necrosis factor-α (TNF-α) in visceral adipose tissue and plasma TNF-α were also assessed. The HGLI diet-induced hypertrophy of adipocytes with adipocyte volume density equal to 97.0%, cross-sectional area of adipocytes equivalent to 1387 μm2 and a total volume of adipocytes of 6.97 cm3 an elevation of 8%, 25%, and 58%, respectively. Furthermore, the HGLI diet increased liver and pancreatic fat deposition, altered and inflamed the intestinal epithelia, and increased TNF-α gene expression (P=0.014) with a positive immunostaining in visceral adipose tissue and high plasma TNF-α in comparison with standard diet. The results suggest that this diet was able to generate changes commonly caused to solid diets with high fat or fructose-rich beverages. To the best of our knowledge, this is the first report in the literature concerning the properties of low-cost, sucrose-rich pellet-diet presenting high glycemic index and high glycemic load efficient on the development of obesity complications in Wistar rats that were subjected to diet-induced obesity. Therefore, the HGLI pellet-diet may be considered an effective tool to be used by the scientific community in experimental research
URI:	https://repositorio.ufrn.br/handle/123456789/57480
Aparece nas coleções:	CCS - DNUT - Artigos publicados em periódicos

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