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https://repositorio.ufrn.br/handle/123456789/57907| Título: | Histopathological prognosis of papillary thyroid carcinoma associated with nutritional status of vitamins A and E |
| Autor(es): | Lyra, Clélia de Oliveira Antoine, Lara Lima Neri, Julianna Lys de Sousa Alves Melo, Thaisa Cristina Tavares de Leite, Isabela Samária Fernandes Santos, Diego Marques da Costa Araújo, Jéssica Nayara Góes de Silva, Ana Gabriella da Costa Lemos Araújo, Nathália Kelly de Ramos, Carlos César de Oliveira Tarrapp, Sheila Ramos de Miranda Henriques Luchessi, André Ducati Ribeira, Karla Danielly da Silva Silbiger, Vivian Nogueira |
| Palavras-chave: | Papillary Thyroid Carcinoma;PTC;Vitamin A;Vitamin E;Histopathological Prognosi;Nutritional Status |
| Data do documento: | Jul-2021 |
| Editor: | European Journal of Clinical Nutrition |
| Referência: | ANTOINE, Lara Lima; NERI, Julianna Lys de Sousa Alves; MELO, Thaisa Cristina Tavares de; LEITE, Isabela Samária Fernandes; SANTOS, Diego Marques da Costa; ARAÚJO, Jéssica Nayara Góes de; SILVA, Ana Gabriella da Costa Lemos; ARAÚJO, Nathália Kelly de; RAMOS, Carlos César de Oliveira; TARRAPP, Sheila Ramos de Miranda Henriques; LUCHESSI, André Ducati; LYRA, Clélia de Oliveira; RIBEIRO, Karla Danielly da Silva; SILBIGER; Vivian Nogueira. Histopathological prognosis of papillary thyroid carcinoma associated with nutritional status of vitamins A and E. European Journal Of Clinical Nutrition, [S.l.], v. 76, n. 3, p. 469-476, 6 jul. 2021. DOI: 10.1038/s41430-021-00976-5. Disponível em: https://www.nature.com/articles/s41430-021-00976-5. Acesso em: 11 mar. 2024. |
| Resumo: | Background/Objectives: Experimental and clinical studies have shown that vitamins A and E can inhibit cancer formation and progression. The unfavourable status of these vitamins can represent risk factors for the disease. This study aimed to evaluate the associations between the nutritional status of vitamins A and E (serum levels and dietary intake) and histopathological outcomes in Papillary Thyroid Carcinoma (PTC) patients. Subjects/Methods: We applied a cross-sectional study (2017–2018) and quantified retinol (ROH) and α-tocopherol (TOH) serum levels and vitamins dietary intake of 46 PTC patients. Serum vitamins were quantified by high efficiency liquid chromatography and vitamins dietary intake was analyzed by 24‐hr dietary recalls. Results: Patients with lower ROH serum levels were more likely to present lymph node metastasis and/or angiolymphatic invasion (p = 0.025). In addition, higher vitamin A and vitamin E intake are related to the absence of extrathyroidal extension (p = 0.013) and lymph node metastasis (p = 0.007), respectively. Our findings suggest that a ROH serum level greater than 2.65 μmol/L in PTC patients may be a protective factor against the presence of lymph node metastasis and angiolymphatic invasion. In addition, vitamin A and E intake may protect against extrathyroidal extension and lymph node metastasis. Conclusions: A favourable nutritional status (higher serum levels and/or intake) of vitamin A and E may be associated with less aggressive tumours in PTC patients |
| URI: | https://repositorio.ufrn.br/handle/123456789/57907 |
| Aparece nas coleções: | CCS - DNUT - Artigos publicados em periódicos |
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