1. Universidade Federal do Rio Grande do Norte
2. Centro de Ciências da Saúde
3. DNUT - Departamento de Nutrição
4. CCS - DNUT - Artigos publicados em periódicos

Título:	Association between kidney function and Framingham risk score in an admixed population of Brazil
Autor(es):	Evangelista, Karine Cavalcanti Maurício de Sena Costa, Brunna Soares Rodrigues Freitas, Erika Paula Silva Cruz, Marina Sampaio Duarte, Victor Hugo Rezende Silva, Ananília Medeiros Gomes da Santos, Isabelle Cristina Clemente dos Santos, Jéssica Cavalcante dos Rezende, Adriana Augusto Silbiger, Vivian Nogueira
Palavras-chave:	Chronic kidney disease;Cardiovascular diseases;Risk factors;Glomerular filtration rate;Framingham Risk Score - FRS
Data do documento:	Fev-2018
Editor:	Brazilian Journal of Pharmaceutical Sciences
Referência:	COSTA, Brunna Soares Rodrigues; FREITAS, Erika Paula Silva; CRUZ, Marina Sampaio; DUARTE, Victor Hugo Rezende; SILVA, Ananília Medeiros Gomes da; SANTOS, Isabelle Cristina Clemente dos; SANTOS, Jéssica Cavalcante dos; REZENDE, Adriana Augusto; EVANGELISTA, Karine Cavalcanti Maurício Sena; SILBIGER, Vivian Nogueira. Association between kidney function and Framingham risk score in an admixed population of Brazil. Brazilian Journal of Pharmaceutical Sciences, [S.l.], v. 53, n. 3, p. 1-8, 1 fev. 2018. DOI: 10.1590/s2175-97902017000317185. Disponível em: https://www.scielo.br/j/bjps/a/DBtDNBTnDc7NKCypzwpqrfj/?lang=en. Acesso em: 25 jul. 2024.
Resumo:	Chronic kidney disease (CKD) increases cardiovascular disease (CVD) risk development. However, the mechanisms of reduced kidney function with CVD risk are unclear. This study aimed to investigate the association between kidney function and Framingham risk score (FRS) in participants with traditional cardiovascular risk factors and normal estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 m² in an admixed population of Brazil. The participants were divided into three groups according to FRS: low risk group with 0% to <10%, moderate risk group with ≥10% to 20% and high risk group with >20%. The eGFR was calculated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). Data from participants were collected by questionnaire, and blood and urine samples were collected to analyze biochemical markers. A total of 214 subjects aged 53±10 years old was collected. There were 77 individuals in low risk group, 59 in moderate risk group and 78 in high-risk group. Mean eGFRCKD-EPI was 89.39±15.05 mL/min/1.73 m² and 90.74±16.17 mL/min/1.73 m2 when race adjustment. The results indicated that there is an increasing the cardiovascular risk with a decreased of eGFR, conforming to a significant inverse correlation observed between eGFR and FRS with Spearman correlation (R²=-0.256, p<0.001; R²=-0.224, p=0.001, when adjusted for race). There was a statistically significant difference in eGFRCKD-EPI (p<0.001) and eGFRCKD-EPI with race adjustment (p=0.002) among risk groups. The data suggests that the reduction eGFR is associated with elevated FRS among Brazilian adults without CKD. Furthermore, the results suggest that race adjustment it’s not necessary in Brazilian population
URI:	https://repositorio.ufrn.br/handle/123456789/59885
Aparece nas coleções:	CCS - DNUT - Artigos publicados em periódicos

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