The Bisindole Alkaloid Caulerpin, from seaweeds of the Genus Caulerpa, attenuated colon damage in murine colitis model

Lucena, Alessandra Marinho Miranda; Souza, Cássio R. M.; Jales, Jéssica T.; Guedes, Paulo Marcos da Matta; Miranda, George E. C. de; Moura, Adolpho M. A. de; Araújo-Júnior, João X.; Nascimento, George J.; Scortecci, Kátia Castanho; Santos, Barbara V. O.; Souto, Janeusa Trindade de

The Bisindole Alkaloid Caulerpin, from seaweeds of the Genus Caulerpa, attenuated colon damage in murine colitis model

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dc.contributor.author	Lucena, Alessandra Marinho Miranda
dc.contributor.author	Souza, Cássio R. M.
dc.contributor.author	Jales, Jéssica T.
dc.contributor.author	Guedes, Paulo Marcos da Matta
dc.contributor.author	Miranda, George E. C. de
dc.contributor.author	Moura, Adolpho M. A. de
dc.contributor.author	Araújo-Júnior, João X.
dc.contributor.author	Nascimento, George J.
dc.contributor.author	Scortecci, Kátia Castanho
dc.contributor.author	Santos, Barbara V. O.
dc.contributor.author	Souto, Janeusa Trindade de
dc.date.accessioned	2021-03-24T10:17:49Z
dc.date.available	2021-03-24T10:17:49Z
dc.date.issued	2018-09-07
dc.description.resumo	Caulerpin (CLP), an alkaloid from algae of the genus Caulerpa, has shown anti-inflammatory activity. Therefore, this study aimed to analyze the effect of CLP in the murine model of peritonitis and ulcerative colitis. Firstly, the mice were submitted to peritonitis to evaluate which dose of CLP (40, 4, or 0.4 mg/kg) could decrease the inflammatory infiltration in the peritoneum. The most effective doses were 40 and 4 mg/kg. Then, C57BL/6 mice were submitted to colitis development with 3% dextran sulfate sodium (DSS) and treated with CLP at doses of 40 and 4 mg/kg. The disease development was analyzed through the disease activity index (DAI); furthermore, colonic tissue samples were submitted to histological analysis, NFκB determination, and in vitro culture for cytokines assay. Therefore, CLP at 4 mg/kg presented the best results, triggering improvement of DAI and attenuating the colon shortening and damage. This dose was able to reduce the TNF-α, IFN-γ, IL-6, IL-17, and NFκB p65 levels, and increased the levels of IL-10 in the colon tissue. Thus, CLP mice treatment at a dose of 4 mg/kg showed promising results in ameliorating the damage observed in the ulcerative colitis	pt_BR
dc.identifier.citation	LUCENA, Alessandra Marinho Miranda; SOUZA, Cássio R. M.; JALES, Jéssica T.; GUEDES, Paulo Marcos da Matta; MIRANDA, George E. C. de; MOURA, Adolpho M. A. de; ARAÚJO-JÚNIOR, João X.; NASCIMENTO, George J.; SCORTECCI, Kátia Castanho; SANTOS, Barbara V. O.; SOUTO, Janeusa Trindade de. The Bisindole Alkaloid Caulerpin, from seaweeds of the genus Caulerpa, attenuated colon damage in murine colitis model. Marine Drugs, [s. l.], v. 16, n. 9, p. 318, 7 set. 2018. MDPI AG. Disponível em: https://www.mdpi.com/1660-3397/16/9/318. Acesso em: 19 mar. 2021. http://dx.doi.org/10.3390/md16090318	pt_BR
dc.identifier.doi	10.3390/md16090318
dc.identifier.issn	1660-3397 (Online)
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31986
dc.language	en	pt_BR
dc.publisher	MDPI	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	Caulerpin	pt_BR
dc.subject	Ulcerative colitis	pt_BR
dc.subject	Anti-inflammatory activity	pt_BR
dc.subject	Cytokines	pt_BR
dc.subject	Tissue damage	pt_BR
dc.title	The Bisindole Alkaloid Caulerpin, from seaweeds of the Genus Caulerpa, attenuated colon damage in murine colitis model	pt_BR
dc.type	article	pt_BR