Commercial fucoidans from Fucus vesiculosus can be grouped into antiadipogenic and adipogenic agents

dc.contributor.authorOliveira, Ruth Medeiros
dc.contributor.authorCâmara, Rafael Barros Gomes da
dc.contributor.authorMonte, Jessyka Fernanda Santiago
dc.contributor.authorViana, Rony Lucas Silva
dc.contributor.authorMelo, Karoline Rachel Teodosio
dc.contributor.authorQueiroz, Moacir Fernandes
dc.contributor.authorFilgueira, Luciana Guimarães Alves
dc.contributor.authorOyama, Lila Missae
dc.contributor.authorRocha, Hugo Alexandre de Oliveira
dc.date.accessioned2021-01-05T17:20:30Z
dc.date.available2021-01-05T17:20:30Z
dc.date.issued2018-06-04
dc.description.resumoFucus vesiculosus is a brown seaweed used in the treatment of obesity. This seaweed synthesizes various bioactive molecules, one of them being a sulfated polysaccharide known as fucoidan (FF). This polymer can easily be found commercially, and has antiadipogenic and lipolytic activity. Using differential precipitation with acetone, we obtained four fucoidan-rich fractions (F0.5/F0.9/F1.1/F2.0) from FF. These fractions contain different proportions of fucose:glucuronic acid:galactose:xylose:sulfate, and also showed different electrophoretic mobility and antioxidant activity. Using 3T3-L1 adipocytes, we found that all samples had lipolytic action, especially F2.0, which tripled the amount of glycerol in the cellular medium. Moreover, we observed that FF, F1.0, and F2.0 have antiadipogenic activity, as they inhibited the oil red staining by cells at 40%, 40%, and 50%, respectively. In addition, they decreased the expression of key proteins of adipogenic differentiation (C/EBPα, C/EBPβ, and PPARγ). However, F0.5 and F0.9 stimulated the oil red staining at 80% and increased the expression of these proteins. Therefore, these fucoidan fractions have an adipogenic effect. Overall, the data show that F2.0 has great potential to be used as an agent against obesity as it displays better antioxidant, lipolytic and antiadipogenic activities than the other fucoidan fractions that we testedpt_BR
dc.identifier.citationOLIVEIRA, Ruth Medeiros; CÂMARA, Rafael Barros Gomes da; MONTE, Jessyka Fernanda Santiago; VIANA, Rony Lucas Silva; MELO, Karoline Rachel Teodosio; QUEIROZ, Moacir Fernandes; FILGUEIRA, Luciana Guimarães Alves; OYAMA, Lila Missae; ROCHA, Hugo Alexandre Oliveira. Commercial fucoidans from Fucus vesiculosus can be grouped into antiadipogenic and adipogenic agents. Marine Drugs, [s. l.], v. 16, n. 6, p. 193-206, 4 jun. 2018. MDPI AG. Disponível em: https://www.mdpi.com/1660-3397/16/6/193. Acesso em: 03 ago. 2020. http://dx.doi.org/10.3390/md16060193.pt_BR
dc.identifier.doi10.3390/md16060193
dc.identifier.issn1660-3397 (online)
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/31193
dc.languageenpt_BR
dc.publisherMDPIpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subject3T3-L1 cellspt_BR
dc.subjectFucanpt_BR
dc.subjectLipolyticpt_BR
dc.subjectObesitypt_BR
dc.subjectBrown seaweedpt_BR
dc.titleCommercial fucoidans from Fucus vesiculosus can be grouped into antiadipogenic and adipogenic agentspt_BR
dc.typearticlept_BR

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