Carvedilol decrease IL-1β and TNF-α, inhibits MMP-2, MMP-9, COX-2, and RANKL expression, and up-regulates OPG in a rat model of periodontitis

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dc.contributor.authorAraújo Júnior, Raimundo Fernandes de
dc.contributor.authorSouza, Tatiana Oliveira
dc.contributor.authorMedeiros, Caroline Addison Carvalho Xavier de
dc.contributor.authorSouza, Lélia Batista de
dc.contributor.authorFreitas, Maria de Lourdes
dc.contributor.authorLucena, Hévio Freitas de
dc.contributor.authorAlves, Maria do Socorro Costa Feitosa
dc.contributor.authorAraújo, Aurigena Antunes de
dc.date.accessioned2017-09-11T14:39:09Z
dc.date.available2017-09-11T14:39:09Z
dc.date.issued2013
dc.description.resumoPeriodontal diseases are initiated primarily by Gram-negative, tooth-associated microbial biofilms that elicit a host response that causes osseous and soft tissue destruction. Carvedilol is a β-blocker used as a multifunctional neurohormonal antagonist that has been shown to act not only as an anti-oxidant but also as an anti-inflammatory drug. This study evaluated whether Carvedilol exerted a protective role against ligature-induced periodontitis in a rat model and defined how Carvedilol affected metalloproteinases and RANKL/RANK/OPG expression in the context of bone remodeling. Rats were randomly divided into 5 groups (n = 10/group): (1) non-ligated (NL), (2) ligature-only (LO), and (3) ligature plus Carvedilol (1, 5 or 10 mg/kg daily for 10 days). Periodontal tissue was analyzed for histopathlogy and using immunohistochemical analysis characterized the expression profiles of MMP-2, MMP-9, COX-2, and RANKL/RANK/OPG and determined the presence of IL-1β, IL-10 and TNF-α, myeloperoxidase (MPO), malonaldehyde (MDA) and, glutathione (GSH). MPO activity in the group with periodontal disease was significantly increased compared to the control group (p<0.05). Rats treated with 10 mg/kg Carvedilol presented with significantly reduced MPO and MDA concentrations (p<0.05) in addition to presenting with reduced levels of the pro-inflammatory cytokines IL-1 β and TNF-α (p<0.05). IL-10 levels in Carvedilol-treated rats remained unaltered. Immunohistochemical analysis demonstrated reduced expression of MMP-2, MMP-9, RANK, RANKL, COX-2, and OPG in rats treated with 10 mg/kg Carvedilol. This study demonstrated that Carvedilol affected bone formation/destruction and anti-inflammatory activity in a rat model of periodontitis.pt_BR
dc.identifier.citationARAÚJO JÚNIOR, Raimundo Fernandes de et al. Carvedilol Decrease IL-1β and TNF-α, Inhibits MMP-2, MMP-9, COX-2, and RANKL Expression, and Up-Regulates OPG in a Rat Model of Periodontitis. Plos One , v. 8, n. 7, p. e66391, 2013.pt_BR
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23807
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCarvedilolpt_BR
dc.subjectPeriodontitept_BR
dc.subjectRatospt_BR
dc.titleCarvedilol decrease IL-1β and TNF-α, inhibits MMP-2, MMP-9, COX-2, and RANKL expression, and up-regulates OPG in a rat model of periodontitispt_BR
dc.typearticlept_BR

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