Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors

dc.contributor.authorSouza, Lélia Batista de
dc.contributor.authorCavalcante, Roberta Barroso
dc.contributor.authorLopes, Fernanda Ferreira
dc.contributor.authorSoares, Andréa Ferreira
dc.contributor.authorFreitas, Roseana de Almeida
dc.date.accessioned2017-09-15T13:44:14Z
dc.date.available2017-09-15T13:44:14Z
dc.date.issued2007
dc.description.resumoMyoepithelial cells present a complex immunophenotype, with the expression of proteins varying according to the stage of normal or neoplastic differentiation of the cell. In order to evaluate the immunohistochemical markers expressed by these cells, a panel of antibodies composed of vimentin, calponin and HHF-35 was applied to 28 salivary gland tumors. The results demonstrated a higher percent sensitivity of vimentin and calponin compared to HHF-35. However, calponin and HHF-35 presented a focal labeling pattern in contrast with the diffuse distribution of vimentin. The cells predominantly stained by all tested antibodies included nonluminal cells in duct-like and tubular structures, such as those seen in pleomorphic adenomas and adenoid cystic carcinomas, as well as cells in the cords and nests of polymorphous low-grade adenocarcinomas and peripheral cells of sheets and nests of myoepitheliomas. In conclusion, the combination of calponin and vimentin is suggested for the identification of myoepithelial cells in salivary gland tumors.pt_BR
dc.identifier.citationSOUZA, Lélia Batista de et al . Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors. Brazilian Dental Journal, v. 10, n. 3, p. 38-42, 2007.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1590/S0103-64402007000300003
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23888
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMyoepithelial cellpt_BR
dc.subjectSalivary gland tumorspt_BR
dc.subjectVimentinpt_BR
dc.subjectCalponinpt_BR
dc.subjectHHF-35pt_BR
dc.titleImmunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumorspt_BR
dc.typearticlept_BR

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