Immunoexpression of MMPs-1, -2, and -9 in ameloblastoma and odontogenic adenomatoid tumor
| dc.contributor.author | Ribeiro, Betania Fachetti | |
| dc.contributor.author | Iglesias, Déborah Pitta Paraíso | |
| dc.contributor.author | Nascimento, G. J. F. | |
| dc.contributor.author | Galvão, Hebel Cavalcanti | |
| dc.contributor.author | Medeiros, Ana Miryam Costa de | |
| dc.contributor.author | Freitas, Roseana de Almeida | |
| dc.date.accessioned | 2017-02-02T10:59:27Z | |
| dc.date.available | 2017-02-02T10:59:27Z | |
| dc.date.issued | 2009 | |
| dc.description.resumo | OBJECTIVE: The aim of this study was to evaluate and compare the expression of metalloproteinases-1, -2, and -9 in solid ameloblastoma and adenomatoid odontogenic tumor. METHODS: A total of 20 cases of solid ameloblastoma and 10 cases of adenomatoid odontogenic tumors were selected and immunohistochemically assessed. Metalloproteinases-1, -2, and -9 immunoexpression and their distribution pattern were noted and semiquantitatively scored. The scores obtained were statistically analyzed. RESULTS: Matrix metalloproteinase (MMP)-1 showed a predominant expression in both tumors and was found in stroma and parenchyma. For MMP-2, there was a varied expression, with 80% and 60% of immunoreactive tumor cells in ameloblastoma and adenomatoid odontogenic tumor respectively. Regarding stromal cells, 65% of ameloblastomas and 80% of adenomatoid odontogenic tumors showed positivity. There was immunoexpression of the MMP-9 in parenchymal and stromal cells in all cases of both tumors analyzed. A statistically significant difference in the expression of MMP-1 in relation to the expression of MMP-2 and -9 in ameloblastomas (P < 0.001) was observed. CONCLUSION: The results suggest that these metalloproteinases are related to growth and progression of tumors analyzed, and particularly in ameloblastoma, its highest aggressiveness may be, in part, a result of the active participation of the stromal cells and their products, such as the MMPs studied. | pt_BR |
| dc.identifier.citation | RIBEIRO, B. F. et al. Immunoexpression of MMPs-1, -2, and -9 in ameloblastoma and odontogenic adenomatoid tumor. Oral Diseases, v. 15, n. 7, p. 472-477, 2009. | pt_BR |
| dc.identifier.uri | https://repositorio.ufrn.br/jspui/handle/123456789/21845 | |
| dc.language | eng | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.subject | Ameloblastoma | pt_BR |
| dc.subject | Odontogenic adenomatoid tumor | pt_BR |
| dc.subject | Matrix metalloproteinases | pt_BR |
| dc.subject | Extracellular matrix | pt_BR |
| dc.title | Immunoexpression of MMPs-1, -2, and -9 in ameloblastoma and odontogenic adenomatoid tumor | pt_BR |
| dc.type | article | pt_BR |
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