High-risk human papillomavirus (HPV) is not associated with p53 and bcl-2 expression in oral squamous cell carcinomas

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dc.contributor.authorOliveira, Márcio Campos
dc.contributor.authorSoares, Rosilene Calazans
dc.contributor.authorPinto, Leão Pereira
dc.contributor.authorSouza, Lélia Batista de
dc.contributor.authorMedeiros, Sílvia Regina Batistuzzo de
dc.contributor.authorCosta, Antonio de Lisboa Lopes
dc.date.accessioned2017-09-11T14:49:37Z
dc.date.available2017-09-11T14:49:37Z
dc.date.issued2009
dc.description.resumoObjective To determine the frequency and type of human papillomavirus (HPV) in oral squamous cell carcinomas (OSCC), as well as to identify a possible association between HPV infection and the expression pattern of p53 and bcl-2, and identify whether the oral HPV infection is a characteristic finding in our sample. Methods We performed polymerase chain reaction and dot blot hybridization for the detection of HPV DNA in paraffin sections as well as immunohistochemical analysis of p53 and bcl-2 in our sample. Results Twenty-six cases (29.5%) were positive for the virus by PCR. Dot blot hybridization identified HPV 18 in 21 (80.8%) cases, HPV 16 in one (3.8%) case and a combination of the two types in the four (15.4%) remaining cases. No other type of HPV was detected in the sample. Immunohistochemistry showed p53 in 26 (60.4%) cases and bcl-2 in 17 (39.5%) ones. No significant association was observed between the presence of HPV and the expression of the proteins studied (p = 0.988 and p = 0.748, respectively). Conclusions Although this investigation have detected only 29.5% of HR-HPV DNA in OSCC, it is possible that this virus contribute to the development of some case of this tumor. Furthermore, it seems that the immunohistochemical expression of p53 and bcl-2 and the presence of HPV DNA are independent events in OSCC.pt_BR
dc.identifier.citationOLIVEIRA, Márcio Campos et al. High-risk human papillomavirus (HPV) is not associated with p53 and bcl-2 expression in oral squamous cell carcinomas. Auris Nasus Larynx, v. 36, n. 4, p. 450-456, 2009.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.anl.2008.10.011
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23816
dc.languageengpt_BR
dc.publisherELSEVIERpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectHPVpt_BR
dc.subjectTumor suppressor proteinspt_BR
dc.subjectOncoproteinspt_BR
dc.subjectPCRpt_BR
dc.subjectHybridizationpt_BR
dc.subjectImmunohistochemistrypt_BR
dc.titleHigh-risk human papillomavirus (HPV) is not associated with p53 and bcl-2 expression in oral squamous cell carcinomaspt_BR
dc.typearticlept_BR

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