Immunohistochemical analysis of bone resorption regulators (RANKL and OPG), angiogenic index, and myofibroblasts in syndrome and non-syndrome odontogenic keratocysts

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dc.contributor.authorNonaka, Cassiano Francisco Weege
dc.contributor.authorCavalcante, Roberta Barroso
dc.contributor.authorNogueira, Renato Luiz Maia
dc.contributor.authorSouza, Lélia Batista de
dc.contributor.authorPinto, Leão Pereira
dc.date.accessioned2017-09-11T14:39:32Z
dc.date.available2017-09-11T14:39:32Z
dc.date.issued2012
dc.description.resumoObjective The aim of this study was to immunohistochemically analyse bone resorption regulators (receptor activator of nuclear factor kappa B ligand [RANKL] and osteoprotegerin [OPG]), angiogenic index, and myofibroblasts in Gorlin syndrome-related odontogenic keratocysts (SOKCs) and non-syndrome odontogenic keratocysts (NSOKCs). Study design Twenty-two SOKCs, 22 primary NSOKCs, and eight recurrent NSOKCs were evaluated by immunohistochemistry using anti-RANKL and anti-OPG antibodies. The angiogenic index was determined by microvessel count (MVC) using anti-CD34 antibody. Anti-α-smooth muscle actin (α-SMA) antibody was used for the identification of myofibroblasts. Results Analysis of the expression of RANKL and OPG in the epithelial lining and fibrous capsule did not reveal significant differences between groups (P > 0.05). In the epithelial lining, the RANKL/OPG ratio was RANKL < OPG and RANKL = OPG in most primary NSOCKs (54.5%) and SOKCs (59.1%), respectively (P > 0.05). In the fibrous capsule, the ratio was RANKL = OPG in most primary (81.8%) and recurrent NSOKCs (75.0%) and in most SOKCs (45.5%) (P > 0.05). No significant differences in the angiogenic index or number of myofibroblasts were observed between primary NSOKCs, recurrent NSOKCs, and SOKCs (P > 0.05). Conclusions The present results suggest that differences in the biological behaviour of SOKCs and NSOKCs may not be related to the expression of RANKL and OPG, to the RANKL/OPG ratio, to the angiogenic index, or to the number of myofibroblasts in these lesions.pt_BR
dc.identifier.citationNONAKA, Cassiano Francisco Weege et al. Immunohistochemical analysis of bone resorption regulators (RANKL and OPG), angiogenic index, and myofibroblasts in syndrome and non-syndrome odontogenic keratocysts. Archives of Oral Biology , v. 57, n. 3, p. 230-237, 2012.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.archoralbio.2011.08.002
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23808
dc.languageengpt_BR
dc.publisherELSEVIERpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectOdontogenic keratocystpt_BR
dc.subjectReceptor activator of nuclear factor kappa B ligandpt_BR
dc.subjectOsteoprotegerinpt_BR
dc.subjectCD34pt_BR
dc.subjectMyofibroblastpt_BR
dc.subjectImmunohistochemistrypt_BR
dc.titleImmunohistochemical analysis of bone resorption regulators (RANKL and OPG), angiogenic index, and myofibroblasts in syndrome and non-syndrome odontogenic keratocystspt_BR
dc.typearticlept_BR

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