Efeito da terapia fotodinâmica antimicrobiana com Cloro-alumínio ftalocianina nos parâmetros clínicos de pacientes com periodontite crônica

Abstract

Chloro-aluminum phthalocyanine (AlClPc), as a photosensitizing drug, has shown favorable results in clinical and laboratory studies; however, there are no clinical trials evaluating its application in antimicrobial photodynamic therapy (PDTa) in chronic periodontitis (CP). Thus, the objective of this study was to evaluate the effect of adjuvant PDTa with AlClPc on scaling and root planing (SRP) in periodontal clinical parameters of patients with CP. The study was characterized as split-mouth randomized clinical trial, double-blind, longitudinal and prospective. Fifty-four periodontal sites were randomly distributed into two groups: 27 in the test group (SRP + PDTa) and 27 in the control group (SRP). The SRP was performed in a single session and clinical periodontal parameters of plaque index (PI), bleeding on probing (BOP), probing depth (PD) and clinical attachment level (CAL) were assessed at the baseline ( T0) and after 3 months (T3) of the PDTa. Data were submitted to statistical analysis by the non-parametric Wilcoxon and Mann-Whitney tests, at a significance level of 5%. There was a reduction in the BOP in both treatment groups, with adjuvant PDTa (p = 0.003) and only SRP (p = 0.001), between T0 and T3. In the inter-group comparison there was no statistically significant difference. PD reduction and clinical insertion gain were observed for both treatment groups (p <0.05) after 3 months of therapy. In the inter-group comparison there was no statistically significant difference (p> 0.05) in any of the times analyzed. PDTa with AlClPc, adjuvant to RACR, did not provide additional benefits in reducing depth of probing and gain of clinical insertion.