Extração de compostos fenólicos do bagaço do caju (Anacardium occidentale L.) visando aplicação cosmética

dc.contributor.advisorLima, Ádley Antonini Neves de
dc.contributor.advisor-co1Alves, Fábia Rafaella Silva
dc.contributor.advisor-co1IDhttps://orcid.org/0000-0002-6634-7125pt_BR
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/4939875215993291pt_BR
dc.contributor.advisorIDhttps://orcid.org/0000-0002-3798-3915pt_BR
dc.contributor.advisorLatteshttp://lattes.cnpq.br/4061809277935577pt_BR
dc.contributor.authorAlves, Fábia Rafaella Silva Alves
dc.contributor.authorSena, Ana Beatriz da Silva Araújo
dc.contributor.authorPadilha, Carlos Eduardo de Araújo
dc.contributor.authorAssis, Cristiane Fernandes de
dc.contributor.authorSilva, Bárbara Janaína Paula da
dc.contributor.authorLima, Emersom Silva
dc.contributor.authorJúnior, Francisco Canindé de Sousa
dc.contributor.authorConverti, Attilio
dc.contributor.authorLima, Ádley Antonini Neves de
dc.contributor.authorIDhttps://orcid.org/0000-0001-7142-4626pt_BR
dc.contributor.authorLatteshttp://lattes.cnpq.br/3654181559500206pt_BR
dc.contributor.referees1Lima, Ádley Antonini Neves de
dc.contributor.referees1IDhttps://orcid.org/0000-0002-3798-3915pt_BR
dc.contributor.referees1Latteshttp://lattes.cnpq.br/4061809277935577pt_BR
dc.contributor.referees2Assis, Cristiane Fernandes de
dc.contributor.referees2IDhttps://orcid.org/0000-0001-7595-5395pt_BR
dc.contributor.referees2Latteshttp://lattes.cnpq.br/0034694007210837pt_BR
dc.contributor.referees3Oliveira, Verônica da Silva
dc.contributor.referees3Latteshttp://lattes.cnpq.br/3459683395706868pt_BR
dc.date.accessioned2023-12-14T20:28:44Z
dc.date.available2023-12-14T20:28:44Z
dc.date.issued2023-12-01
dc.description.abstractThe cashew apple bagasse (CAB) is an agroindustrial byproduct composed of lignocellulose and serves as a significant source of phenolic compounds. In this context, the aim was to obtain a phenolic-rich extract using CAB for cosmetic applications. CAB underwent pretreatments with liquid hot water (LHW) and steam explosion (SE), characterized by FTIR, XRD, and lignocellulosic composition. Subsequently, enzymatic-assisted extraction (EAE) of pre-treated CAB was assessed using a cellulolytic cocktail. The effects of enzyme load, solid load, and incubation time were optimized through a 23 central composite rotational design. Extracts were evaluated for phenolic composition, in vitro and cellular antioxidant activity, sugar content, in vitro sun protection factor (SPF), and cytotoxicity. Results demonstrated structural modifications in the residue through the removal of amorphous fractions. The HW pretreatment combined with enzymatic extraction facilitated phenolic release (75.13 ± 3.5 mg GAE/L) and enhanced antioxidant activity (72.81% for DPPH and 241.04 ± 1.7 µM EQ Trolox/L for ABTS). Furthermore, the extract was non-toxic, with cellular viability exceeding 95% in MRC-5. Statistical design indicated optimal conditions of 80 h incubation and 8% solid load. The cashew extract exhibited cellular antioxidant activity (36.03% inhibition of Reactive Oxygen Species) and indications of solar photoprotection (SPF 6.4). Therefore, obtaining a cashew extract proves promising for anti-aging cosmetic formulations.pt_BR
dc.description.resumoThe cashew apple bagasse (CAB) is an agroindustrial byproduct composed of lignocellulose and serves as a significant source of phenolic compounds. In this context, the aim was to obtain a phenolic-rich extract using CAB for cosmetic applications. CAB underwent pretreatments with liquid hot water (LHW) and steam explosion (SE), characterized by FTIR, XRD, and lignocellulosic composition. Subsequently, enzymatic-assisted extraction (EAE) of pre-treated CAB was assessed using a cellulolytic cocktail. The effects of enzyme load, solid load, and incubation time were optimized through a 23 central composite rotational design. Extracts were evaluated for phenolic composition, in vitro and cellular antioxidant activity, sugar content, in vitro sun protection factor (SPF), and cytotoxicity. Results demonstrated structural modifications in the residue through the removal of amorphous fractions. The HW pretreatment combined with enzymatic extraction facilitated phenolic release (75.13 ± 3.5 mg GAE/L) and enhanced antioxidant activity (72.81% for DPPH and 241.04 ± 1.7 µM EQ Trolox/L for ABTS). Furthermore, the extract was non-toxic, with cellular viability exceeding 95% in MRC-5. Statistical design indicated optimal conditions of 80 h incubation and 8% solid load. The cashew extract exhibited cellular antioxidant activity (36.03% inhibition of Reactive Oxygen Species) and indications of solar photoprotection (SPF 6.4). Therefore, obtaining a cashew extract proves promising for anti-aging cosmetic formulations.pt_BR
dc.description.sponsorshipCNPQ e CAPESpt_BR
dc.identifier.citationSENA, Ana Beatriz da Silva Araújo. Extração de compostos fenólicos do bagaço do caju (Anacardium occidentale L.) visando aplicação cosmética. Orientador: Ádley Antonini Neves de Lima. 2023. 51 f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2023.pt_BR
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/55942
dc.languageenpt_BR
dc.publisherUniversidade Federal do Rio Grande do Nortept_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentDEPARTAMENTO DE FARMÁCIApt_BR
dc.publisher.initialsUFRNpt_BR
dc.publisher.programFarmáciapt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectCashew apple bagassept_BR
dc.subjectEnzyme-assisted extractionpt_BR
dc.subjectPhenolic compoundspt_BR
dc.subjectAntioxidant activitypt_BR
dc.subjectCosmeticpt_BR
dc.subjectBagaço de cajupt_BR
dc.subjectExtração assistida por enzimapt_BR
dc.subjectCompostos fenólicospt_BR
dc.subjectAtividade antioxidantept_BR
dc.subjectCosméticopt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDEpt_BR
dc.titleExtração de compostos fenólicos do bagaço do caju (Anacardium occidentale L.) visando aplicação cosméticapt_BR
dc.title.alternativeExtraction of phenolic compounds from cashew apple bagasse (Anacardium occidentale L.) aiming at cosmetic applicationpt_BR
dc.typebachelorThesispt_BR

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