Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation

dc.contributor.authorOliveira, Leticia Castelo Branco Peroba
dc.contributor.authorQueiroz, Moacir Fernandes
dc.contributor.authorFidelis, Gabriel Pereira
dc.contributor.authorMelo, Karoline Rachel Teodosio
dc.contributor.authorCâmara, Rafael Barros Gomes da
dc.contributor.authorAlves, Monique Gabriela das Chagas Faustino
dc.contributor.authorCosta, Leandro Silva
dc.contributor.authorTeixeira, Dárlio Inácio Alves
dc.contributor.authorMelo-Silveira, Raniere Fagundes
dc.contributor.authorRocha, Hugo Alexandre de Oliveira
dc.date.accessioned2021-01-05T16:53:18Z
dc.date.available2021-01-05T16:53:18Z
dc.date.issued2020-04-28
dc.description.resumoThe genus Gracilaria synthesizes sulfated polysaccharides (SPs). Many of these SPs, including those synthesized by the edible seaweed Gracilaria birdiae, have not yet been adequately investigated for their use as potential pharmaceutical compounds. Previous studies have demonstrated the immunomodulatory effects of sulfated galactans from G. birdiae. In this study, a galactan (GB) was extracted from G. birdiae and evaluated by cell proliferation and antioxidant tests. GB showed no radical hydroxyl (OH) and superoxide (O2−) scavenging ability. However, GB was able to donate electrons in two further different assays and presented iron- and copper-chelating activity. Urolithiasis affects approximately 10% of the world’s population and is strongly associated with calcium oxalate (CaOx) crystals. No efficient compound is currently available for the treatment of this disease. GB appeared to interact with and stabilize calcium oxalate dihydrate crystals, leading to the modification of their morphology, size, and surface charge. These crystals then acquired the same characteristics as those found in healthy individuals. In addition, GB showed no cytotoxic effect against human kidney cells (HEK-293). Taken together, our current findings highlight the potential application of GB as an antiurolithic agentpt_BR
dc.identifier.citationOLIVEIRA, Leticia Castelo Branco Peroba; QUEIROZ, Moacir Fernandes; FIDELIS, Gabriel Pereira; MELO, Karoline Rachel Teodosio; CÂMARA, Rafael Barros Gomes; ALVES, Monique Gabriela Chagas Faustino; COSTA, Leandro Silva; TEIXEIRA, Dárlio Inácio Alves; MELO-SILVEIRA, Raniere Fagundes; ROCHA, Hugo Alexandre Oliveira. Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation. Molecules, [s. l.], v. 25, n. 9, p. 2055-2069, 28 abr. 2020. MDPI AG. Disponível em: https://www.mdpi.com/1420-3049/25/9/2055/htm. Acesso em: 03 ago. 2020. http://dx.doi.org/10.3390/molecules25092055.pt_BR
dc.identifier.doi10.3390/molecules25092055
dc.identifier.issn1420-3049 (online)
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/31189
dc.languageenpt_BR
dc.publisherMDPIpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectSulfated galactanpt_BR
dc.subjectRed seaweedpt_BR
dc.subjectAntioxidantpt_BR
dc.subjectCalcium oxalate dihydrate crystalspt_BR
dc.subjectUrolithiasispt_BR
dc.titleAntioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formationpt_BR
dc.typearticlept_BR

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