Baccharis trimera (Less.) DC exhibits an anti-Adipogenic effect by inhibiting the expression of proteins involved in adipocyte differentiation
| dc.contributor.author | Nascimento, Daniele de Souza Marinho do | |
| dc.contributor.author | Oliveira, Ruth Medeiros | |
| dc.contributor.author | Câmara, Rafael Barros Gomes da | |
| dc.contributor.author | Gomes, Dayanne Lopes | |
| dc.contributor.author | Monte, Jessika Fernanda Santiago | |
| dc.contributor.author | Costa, Mariana Santana Santos Pereira | |
| dc.contributor.author | Fernandes, Júlia Moraes | |
| dc.contributor.author | Langassner, Silvana Maria Zucolotto | |
| dc.contributor.author | Rocha, Hugo Alexandre de Oliveira | |
| dc.date.accessioned | 2021-01-05T17:40:13Z | |
| dc.date.available | 2021-01-05T17:40:13Z | |
| dc.date.issued | 2017-06-12 | |
| dc.description.resumo | Baccharis trimera (Less.) DC (gorse) is a plant popularly used for the treatment of obesity. In this study, we prepared three B. trimera extracts aqueous extract (AE), decoction (AE-D), and methanol extract (ME) and investigated their antioxidant effects in six different tests and their anti-adipogenic effect in 3T3-L1 cells. The extracts showed a dose-dependent antioxidant activity in all tests. AE was the most potent antioxidant in copper and ferric ion chelation assays, whereas AE-D was the most potent in superoxide and hydroxyl radical scavenging assays, reducing power assay, and total antioxidant capacity analysis. Only ME showed a cytotoxic effect against 3T3-L1 cells. Lipid accumulation decreased in 3T3-L1 adipocytes in the presence of AE and AE-D extracts (0.5 to 1.0 mg/mL). In addition, the extracts dramatically attenuated the levels of adipogenic transcriptional factors, including CCAAT enhancer-binding protein α (C/EBPα), CCAAT enhancer-binding protein β (C/EBPβ), and gamma receptors by peroxisome proliferators (PPARγ), during adipogenesis. AE-D (1.0 mg/mL) caused an approximately 90% reduction in the levels of these molecules. We propose that B. trimera has an anti-adipogenic effect and could be used in the development of functional foods | pt_BR |
| dc.identifier.citation | NASCIMENTO, Daniele de Souza Marinho do; OLIVEIRA, Ruth Medeiros; CAMARA, Rafael Barros Gomes da; GOMES, Dayanne Lopes; MONTE, Jessika Fernandes Santiago; COSTA, Mariana Santana Santos Pereira; FERNANDES, Júlia Moraes; LANGASSNER, Silvana Maria Zucolotto; ROCHA, Hugo Alexandre Oliveira. Baccharis trimera (Less.) DC exhibits an anti-Adipogenic effect by inhibiting the expression of proteins involved in adipocyte differentiation. Molecules, [s. l.], v. 22, n. 6, p. 972, 12 jun. 2017. MDPI AG. Disponível em: https://www.mdpi.com/1420-3049/22/6/972. Acesso em: 04 ago. 2020. http://dx.doi.org/10.3390/molecules22060972. | pt_BR |
| dc.identifier.doi | 10.3390/molecules22060972 | |
| dc.identifier.issn | 1420-3049 (online) | |
| dc.identifier.uri | https://repositorio.ufrn.br/handle/123456789/31197 | |
| dc.language | en | pt_BR |
| dc.publisher | MDPI | pt_BR |
| dc.rights | Attribution 3.0 Brazil | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/br/ | * |
| dc.subject | Adipogenesis | pt_BR |
| dc.subject | Antioxidant | pt_BR |
| dc.subject | Chlorogenic acid | pt_BR |
| dc.title | Baccharis trimera (Less.) DC exhibits an anti-Adipogenic effect by inhibiting the expression of proteins involved in adipocyte differentiation | pt_BR |
| dc.type | article | pt_BR |
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