Baccharis trimera (Less.) DC exhibits an anti-Adipogenic effect by inhibiting the expression of proteins involved in adipocyte differentiation

dc.contributor.authorNascimento, Daniele de Souza Marinho do
dc.contributor.authorOliveira, Ruth Medeiros
dc.contributor.authorCâmara, Rafael Barros Gomes da
dc.contributor.authorGomes, Dayanne Lopes
dc.contributor.authorMonte, Jessika Fernanda Santiago
dc.contributor.authorCosta, Mariana Santana Santos Pereira
dc.contributor.authorFernandes, Júlia Moraes
dc.contributor.authorLangassner, Silvana Maria Zucolotto
dc.contributor.authorRocha, Hugo Alexandre de Oliveira
dc.date.accessioned2021-01-05T17:40:13Z
dc.date.available2021-01-05T17:40:13Z
dc.date.issued2017-06-12
dc.description.resumoBaccharis trimera (Less.) DC (gorse) is a plant popularly used for the treatment of obesity. In this study, we prepared three B. trimera extracts aqueous extract (AE), decoction (AE-D), and methanol extract (ME) and investigated their antioxidant effects in six different tests and their anti-adipogenic effect in 3T3-L1 cells. The extracts showed a dose-dependent antioxidant activity in all tests. AE was the most potent antioxidant in copper and ferric ion chelation assays, whereas AE-D was the most potent in superoxide and hydroxyl radical scavenging assays, reducing power assay, and total antioxidant capacity analysis. Only ME showed a cytotoxic effect against 3T3-L1 cells. Lipid accumulation decreased in 3T3-L1 adipocytes in the presence of AE and AE-D extracts (0.5 to 1.0 mg/mL). In addition, the extracts dramatically attenuated the levels of adipogenic transcriptional factors, including CCAAT enhancer-binding protein α (C/EBPα), CCAAT enhancer-binding protein β (C/EBPβ), and gamma receptors by peroxisome proliferators (PPARγ), during adipogenesis. AE-D (1.0 mg/mL) caused an approximately 90% reduction in the levels of these molecules. We propose that B. trimera has an anti-adipogenic effect and could be used in the development of functional foodspt_BR
dc.identifier.citationNASCIMENTO, Daniele de Souza Marinho do; OLIVEIRA, Ruth Medeiros; CAMARA, Rafael Barros Gomes da; GOMES, Dayanne Lopes; MONTE, Jessika Fernandes Santiago; COSTA, Mariana Santana Santos Pereira; FERNANDES, Júlia Moraes; LANGASSNER, Silvana Maria Zucolotto; ROCHA, Hugo Alexandre Oliveira. Baccharis trimera (Less.) DC exhibits an anti-Adipogenic effect by inhibiting the expression of proteins involved in adipocyte differentiation. Molecules, [s. l.], v. 22, n. 6, p. 972, 12 jun. 2017. MDPI AG. Disponível em: https://www.mdpi.com/1420-3049/22/6/972. Acesso em: 04 ago. 2020. http://dx.doi.org/10.3390/molecules22060972.pt_BR
dc.identifier.doi10.3390/molecules22060972
dc.identifier.issn1420-3049 (online)
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/31197
dc.languageenpt_BR
dc.publisherMDPIpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectAdipogenesispt_BR
dc.subjectAntioxidantpt_BR
dc.subjectChlorogenic acidpt_BR
dc.titleBaccharis trimera (Less.) DC exhibits an anti-Adipogenic effect by inhibiting the expression of proteins involved in adipocyte differentiationpt_BR
dc.typearticlept_BR

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