Antitryptical, anticoagulant and hemagglutinating activities of Eucalyptus sp. seeds

Santos, Yago Queiroz dos; Carelli, Gabriella Silva Campos; Veras, Bruno Oliveira de; Batista, Virgínia Cunha; França, Anderson Felipe Jácome de; Silva, Márcia Vanusa da; Santos, Elizeu Antunes dos

Antitryptical, anticoagulant and hemagglutinating activities of Eucalyptus sp. seeds

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dc.contributor.author	Santos, Yago Queiroz dos
dc.contributor.author	Carelli, Gabriella Silva Campos
dc.contributor.author	Veras, Bruno Oliveira de
dc.contributor.author	Batista, Virgínia Cunha
dc.contributor.author	França, Anderson Felipe Jácome de
dc.contributor.author	Silva, Márcia Vanusa da
dc.contributor.author	Santos, Elizeu Antunes dos
dc.date.accessioned	2021-01-29T12:31:02Z
dc.date.available	2021-01-29T12:31:02Z
dc.date.issued	2019-01-08
dc.description.resumo	Background: Plant biodiversity has great value for science being an inexhaustible source for new bioactive molecules capable of offering environmentally friendly and innovative solutions for various areas of the industry. The scientific community has increased their interest in the study of plant species in the search of new molecules and to determine their mechanisms of action. Plant seeds are natural sources of bioactive compounds, such as carbohydrates, lipids and proteins with special focus on enzymatic inhibitors which protect them against digestive enzymes of phytopathogens and lectins that play an important role on carbohydrate signalization and metabolism during germination. The objective of the present study was to evaluate and describe the protein profile and to test the hemagglutinating, hemolytic and anticoagulant activities, as well as the antitryptic effect of extracts and fractions obtained from seeds of Eucalyptus species. Methods: The crude protein extract was obtained from the seed of Eucalyptus sp. with 0.02 M sodium phosphate buffer, at pH 6.6, and fractionated using ammonium sulfate in order to study its antitryptical properties as well as the capacity of hemagglutination and influence on hemostasis. Results: The crude extract showed a high effectiveness for trypsin inhibition. For hemagglutinating activity, the ammonium sulfate fraction 0-30% presented better activity, while no hemolytic activity was present in the obtained fractions. For anticoagulation assay, the fraction 0-30% showed better results. Conclusions: Taken together, the obtained results demonstrate the biotechnological potential of Eucalyptus sp. seeds, although further study is still necessary to better isolate as well as describe the bioactive compounds	pt_BR
dc.identifier.citation	SANTOS, Yago Queiroz dos; CARELLI, Gabriella Silva Campos; VERAS, Bruno Oliveira de; BATISTA, Virgínia Cunha; FRANÇA, Anderson Felipe Jácome de; SILVA, Márcia Vanusa da; SANTOS, Elizeu Antunes dos. Antitryptical, anticoagulant and hemagglutinating activities of Eucalyptus sp. seeds. F1000Research, [s. l.], v. 8, p. 28-34, 8 jan. 2019. Disponível em: https://f1000research.com/articles/8-28/v1. Acesso em: 26 jan. 2021. http://dx.doi.org/10.12688/f1000research.17080.1	pt_BR
dc.identifier.doi	10.12688/f1000research.17080.1
dc.identifier.issn	2046-1402
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31320
dc.language	en	pt_BR
dc.publisher	F1000Research	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	Eucalyptus sp.	pt_BR
dc.subject	seed	pt_BR
dc.subject	tripsin inhibitor	pt_BR
dc.title	Antitryptical, anticoagulant and hemagglutinating activities of Eucalyptus sp. seeds	pt_BR
dc.type	article	pt_BR