Sistemas coloidais baseados em copolimero em bloco biocompativel para o aumento da solubilidade do ibuprofeno em meio aquoso

Abstract

Polymeric application in dispersed systems was studied with different concentrations of the biocompatible copolymer known commercially as Kolliphor® in aqueous solutions and its interaction with the drug ibuprofen, which presents low solubility in aqueous médium 2,1%, was investigated through physicochemical properties such as viscosity, turbidity, pH and surface tension. The results showed that solubilization of the drug increased with increasing polymer concentration and a high incorporation value was obtained at concentrations between 15 and 25%, in which more than 90% of the drug was solubilized in aqueous medium.