Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study

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dc.contributor.authorPereira, Joabe dos Santos
dc.contributor.authorFontes, Fabrícia Lima
dc.contributor.authorMedeiros, Sílvia Regina Batistuzzo de
dc.contributor.authorFreitas, Roseana de Almeida
dc.contributor.authorSouza, Lélia Batista de
dc.contributor.authorMiguel, Márcia Cristina da Costa
dc.date.accessioned2017-09-11T12:49:14Z
dc.date.available2017-09-11T12:49:14Z
dc.date.issued2016
dc.description.resumoObjective to evaluate the association between XPD and XRCC3 polymorphisms and oral squamous cell carcinoma (OSCC). Design the sample consisted of 54 cases of OSCC and 40 cases of inflammatory fibrous hyperplasia (IFH). Genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results XPD-Lys/Gln was more common in IFH (n = 28; 70%) than in OSCC (n = 24; 44.4%) (OR: 0.3; p < 0.05). XPD-Gln was more frequent in high-grade lesions (0.48) than in low-grade lesions (0.21) (OR: 3.4; p < 0.05). The Gln/Gln genotype was associated with III and IV clinical stages (OR: 0.07; p < 0.05). XRCC3-Met was more frequent in OSCC (0.49) than in IFH (0.35) (OR: 2.6; p < 0.05). The Met/Met genotype was associated with the presence of metastases (OR: 8.1; p < 0.05) and with III and IV clinical stages (OR: 0.07; p < 0.05). Conclusions in this sample, the frequency of XPD-Gln in IFH suggests that this variant may protect against OSCC. The presence of the XRCC3-Met allele seems to contribute to the development of OSCC, metastases and more advanced stages in these lesions.pt_BR
dc.identifier.citationPEREIRA, Joabe dos Santos et al . Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study. Archives of Oral Biology, v. 64, p. 19-23, 2016.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.archoralbio.2015.12.004
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23803
dc.languageengpt_BR
dc.publisherELSEVIERpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectDNA repair.pt_BR
dc.subjectGenetic polymorphisms.pt_BR
dc.subjectOral cancer.pt_BR
dc.subjectRestriction fragment length polymorphisms.pt_BR
dc.subjectSquamous cell carcinoma.pt_BR
dc.titleAssociation of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot studypt_BR
dc.typearticlept_BR

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