Identificação e Quantificação Eletroquímica da Azitromicina em Amostras de Água Sintética e Real

Abstract

COVID - 19 is an infectious disease caused by a new type of virus called the Severe Acute Syndrome Coronavirus, SARS - CoV - 2. Due to its easy dissemination and nonspecific treatment, numerous therapeutic approaches have been tested, including pharmacological treatment. based on the use of Azithromycin, second-generation semi-synthetic antibiotics belonging to the class of azalide antibiotics. Although its ineffectiveness has been demonstrated, it is currently one of the most consumed drugs in Brazil for the treatment of COVID-19. Drugs are generally classified as Contaminants of Emerging Concern, a class of compounds considered to be a potential or actual threat to the environment. The increased production and consumption of Azithromycin during an atypical situation, such as a pandemic, can have several environmental impacts. In this context, the present work aimed to develop a fast and low-cost electroanalytical procedure for identification and quantification of Azithromycin in samples of synthetic and real water. Therefore, the differential pulse voltammetric technique was used to investigate the oxidation behavior of AZI against different electrochemical sensors in different electrolytes. The data obtained indicated that the Au electrode showed better performance for detection and quantification of AZI in an electrolyte solution of NaHCO3. The oxidation peaks for the species were obtained: the first at E = 0.15V and the second at E = 0.625V. The determination coefficients were r2 = 0.966 and r2 = 0.943, respectively. The model was linear for the range of 0.59 - 1.4 ppm for both observed peaks. The data obtained were submitted to mathematical deconvolution treatment to separate the peaks of the electrolyte and the analyte observed at E = 0.635V.