Alterations in the immunoexpression of claudin-1 between different grades of oral epithelial dysplasias
| dc.contributor.author | Carvalho, Marianne de Vasconcelos | |
| dc.contributor.author | Pereira, Joabe dos Santos | |
| dc.contributor.author | Costa, Antonio de Lisboa Lopes | |
| dc.contributor.author | Souza, Lelia Batista de | |
| dc.contributor.author | Freitas, Roseana de Almeida | |
| dc.contributor.author | Miguel, Marcia Cristina da Costa | |
| dc.date.accessioned | 2017-01-30T12:24:59Z | |
| dc.date.available | 2017-01-30T12:24:59Z | |
| dc.date.issued | 2010 | |
| dc.description.resumo | Claudins are transmembrane proteins that play a role in cell proliferation and adhesion and tumourigenesis. This study evaluated the immunoexpression of claudin-1 in the oral epithelial dysplasia (OED) (19 mild, 26 moderate, 3 severe). Diffuse staining predominated in mild (89.4%) and moderate (80.8%) OEDs. Immunoexpression in the middle and upper third was observed in all mild cases, whereas in moderate/severe dysplasias staining was observed in the upper third in 41.4% of cases, in the upper and middle third in 41.4%, and in the upper, middle and lower third in 17.2% (P<0.05). All mild OEDs and 73.1% of moderate cases presented only membrane staining, whereas membrane/cytoplasmic staining was observed in severe cases. Staining intensity was weak in 60% of parakeratinized OEDs and moderate/strong in orthokeratinized OEDs (60.8%) (P>0.05). The differences in the immunoexpression of claudin-1 between different grades of OEDs suggest the involvement of this protein in the progression of dysplasias. | pt_BR |
| dc.identifier.citation | CARVALHO, Marianne de Vasconcelos et al. Alterations in the immunoexpression of claudin-1 between different grades of oral epithelial dysplasias. Archives of Oral Biology, v. 55, n. 4, p. 261-267, 2010. | pt_BR |
| dc.identifier.uri | https://repositorio.ufrn.br/jspui/handle/123456789/21793 | |
| dc.language | eng | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.subject | Oral epithelial dysplasia | pt_BR |
| dc.subject | Claudin-1 | pt_BR |
| dc.subject | Tight junctions | pt_BR |
| dc.subject | Immunohistochemical | pt_BR |
| dc.subject | Potentially malignant lesion | pt_BR |
| dc.title | Alterations in the immunoexpression of claudin-1 between different grades of oral epithelial dysplasias | pt_BR |
| dc.type | article | pt_BR |
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