Anti-IIa activity and antitumor properties of a hybrid heparin/heparan sulfate-like compound from Litopenaeus vannamei shrimp

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dc.contributor.authorBrito, Adriana da Silva
dc.contributor.authorCavalcante, Rômulo S.
dc.contributor.authorCavalheiro, Renan P.
dc.contributor.authorPalhares, Laís C. G. F.
dc.contributor.authorNobre, Leonardo Thiago Duarte Barreto
dc.contributor.authorSouza, Giulianna Paiva Viana de Andrade
dc.contributor.authorNader, Helena B.
dc.contributor.authorLima, Marcelo A.
dc.contributor.authorChavante, Suely Ferreira
dc.date.accessioned2020-12-15T14:44:31Z
dc.date.available2020-12-15T14:44:31Z
dc.date.issued2018-06-30
dc.description.resumoIn this present study, the anti-IIa activity and the antitumor properties of a hybrid heparin/heparan sulfate-like compound (sH/HS) from Litopenaeus vannamei shrimp heads are related. In addition to inhibiting 90.7% of thrombin activity at the lowest tested concentration (0.5 μg/mL), sH/HS compound stimulated the synthesis of antithrombotic heparan sulfate by endothelial cells in a dose-dependent manner. In vitro experiments demonstrated that the molecule from shrimp displayed a potent anti-angiogenic effect, reducing over 80% of the tubular structures formation at 50 and 100 μg/mL. In addition, sH/HS compound was able to inhibit the migration of B16F10 cells at all tested concentrations without affecting the cell viability. Although the studied compound had no effect on the proliferation of such cells during a period of 24 h, it had a significant long-term antiproliferative effect, reducing about 80% of colony formation and anchorage-independent growth at 50 and 100 μg/mL concentrations. When its effectiveness was tested in vivo, it was demonstrated that sH/HS promoted a reduction of more than 90% of tumor growth. In the context of thromboembolic disorders associated with cancer, such findings make the sH/HS compound an excellent target for studies on inhibiting of development and tumor progression, and the prevention of coagulopathiespt_BR
dc.identifier.citationBRITO, Adriana da Silva; CAVALCANTE, Rômulo S.; CAVALHEIRO, Renan P.; PALHARES, Laís C. G. F.; NOBRE, Leonardo Thiago Duarte Barreto; SOUZA, Giulianna Paiva Viana de Andrade; NADER, Helena B.; LIMA, Marcelo A.; CHAVANTE, Suely Ferreira Anti-IIa activity and antitumor properties of a hybrid heparin/heparan sulfate-like compound from Litopenaeus vannamei shrimp. International Journal Of Biological Macromolecules, [s. l.], v. 118, p. 1470-1478, out. 2018. Elsevier BV. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0141813018311577?via%3Dihub#!. Acesso em: 21 set. 2020. http://dx.doi.org/10.1016/j.ijbiomac.2018.06.143pt_BR
dc.identifier.doi10.1016/j.ijbiomac.2018.06.143
dc.identifier.issn0141-8130 (print)
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/30995
dc.languageenpt_BR
dc.publisherElsevierpt_BR
dc.subjectMarine invertebratept_BR
dc.subjectSulfated polysaccharidept_BR
dc.subjectCancerpt_BR
dc.titleAnti-IIa activity and antitumor properties of a hybrid heparin/heparan sulfate-like compound from Litopenaeus vannamei shrimppt_BR
dc.typearticlept_BR

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