Use este identificador para citar ou linkar para este item: https://repositorio.ufrn.br/jspui/handle/123456789/23117
Título: Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report
Autor(es): Osório, Flávia de L.
Sanches, Rafael F.
Macedo, Ligia R.
Santos, Rafael G. dos
Maia-de-Oliveira, João P.
Wichert-Ana, Lauro
Araujo, Draulio B. de
Riba, Jordi
Crippa, José A.
Hallak, Jaime E.
Palavras-chave: psychedelic agents;dimethyltryptamine;harmine;monoamine oxidase inhibitors;monoamine oxidase inhibitors;therapeutic use
Data do documento: 2015
Citação: OSORIO, Flávia de L. et al . Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report. Rev. Bras. Psiquiatr., São Paulo, v. 37, n. 1, p. 13-20, mar. 2015.
metadata.dc.description.resumo: Objectives: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions. This study sought to evaluate the effects of a single dose of AYA in six volunteers with a current depressive episode. Methods: Open-label trial conducted in an inpatient psychiatric unit. Results: Statistically significant reductions of up to 82% in depressive scores were observed between baseline and 1, 7, and 21 days after AYA administration, as measured on the Hamilton Rating Scale for Depression (HAM-D), the Montgomery-Åsberg Depression Rating Scale (MADRS), and the Anxious-Depression subscale of the Brief Psychiatric Rating Scale (BPRS). AYA administration resulted in nonsignificant changes in Young Mania Rating Scale (YMRS) scores and in the thinking disorder subscale of the BPRS, suggesting that AYA does not induce episodes of mania and/or hypomania in patients with mood disorders and that modifications in thought content, which could indicate psychedelic effects, are not essential for mood improvement. Conclusions: These results suggest that AYA has fast-acting anxiolytic and antidepressant effects in patients with a depressive disorder.
URI: http://hdl.handle.net/123456789/23117
Aparece nas coleções:ICe - Artigos publicados em periódicos

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression.pdfDraulioAraujo_ICe_Antidepressant effects_2015194,26 kBAdobe PDFThumbnail
Visualizar/Abrir


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.