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Title: Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog
Authors: Sirko, Swetlana
Behrendt, Gwendolyn
Johansson, Pia Annette
Tripathi, Pratibha
Costa, Marcos Romualdo
Bek, Sarah
Heinrich, Christophe
Tiedt, Steffen
Colak, Dilek
Dichgans, Martin
Fischer, Isabel Rebekka
Plesnila, Nikolaus
Staufenbiel, Matthias
Haass, Christian
Snapyan, Marina
Saghatelyan, Armen
Li-Huei, Tsai
Fischer, André
Grobe, Kay
Dimou, Leda
Götz, Magdalena
Keywords: Reactive Glia;Brain Acquire;Stem Cell Properties;Sonic Hedgehog
Issue Date: 4-Apr-2013
Portuguese Abstract: As a result of brain injury, astrocytes become activated and start to proliferate in the vicinity of the injury site. Recently, we had demonstrated that these reactive astrocytes, or glia, can form self-renewing and multipotent neurospheres in vitro. In the present study, we demonstrate that it is only invasive injury, such as stab wounding or cerebral ischemia, and not noninvasive injury conditions, such as chronic amyloidosis or induced neuronal death, that can elicit this increase in plasticity. Furthermore, we find that Sonic hedgehog (SHH) is the signal that acts directly on the astrocytes and is necessary and sufficient to elicit the stem cell response both in vitro and in vivo. These findings provide a molecular basis for how cells with neural stem cell lineage emerge at sites of brain injury and imply that the high levels of SHH known to enter the brain from extraneural sources after invasive injury can trigger this response.
ISSN: 1934-5909
Appears in Collections:ICe - Artigos publicados em periódicos

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