Please use this identifier to cite or link to this item:
Title: OLMα2 cells bidirectionally modulate learning
Authors: Siwani, Samer
França, Arthur S. C.
Mikulovic, Sanja
Reis, Amilcar
Hilscher, Markus M.
Edwards, Steven J.
Leão, Richardson N.
Tort, Adriano B. L.
Kullander, Klas
Keywords: OLM cells;object recognition;passive inhibitory avoidance;memory
Issue Date: Jul-2018
Citation: SIWANI, S. et al. OLMa2 cells bidirectionally modulate learning, Neuron, v. 99, n.1, jul./2018.
Portuguese Abstract: Inhibitory interneurons participate in mnemonic processes. However, defined roles for identified interneuron populations are scarce. A subpopulation of oriens lacunosum-moleculare (OLM) interneurons genetically defined by the expression of the nicotinic receptor α2 subunit has been shown to gate information carried by either the temporoammonic pathway or Schaffer collaterals in vitro. Here we set out to determine whether selective modulation of OLMα2 cells in the intermediate CA1 affects learning and memory in vivo. Our data show that intermediate OLMα2 cells can either enhance (upon their inhibition) or impair (upon their activation) object memory encoding in freely moving mice, thus exerting bidirectional control. Moreover, we find that OLMα2 cell activation inhibits fear-related memories and that OLMα2 cells respond differently to nicotine in the dorsoventral axis. These results suggest that intermediate OLMα2 cells are an important component in the CA1 microcircuit regulating learning and memory processes.
Appears in Collections:ICe - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
RichardsonLeao_ICe_2018_OLMa2 cells bidirectionally.pdfRichardsonLeao_ICe_2018_OLMa2 cells bidirectionally2,44 MBAdobe PDFThumbnail

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.