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https://repositorio.ufrn.br/handle/123456789/25830
Título: | Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor |
Autor(es): | Mikulovic, Sanja Restrepo, Carlos Ernesto Siwani, Samer Bauer, Pavol Pupe, Stefano Tort, Adriano Bretanha Lopes Kullander, Klas Leão, Richardson Naves |
Palavras-chave: | Ventral hippocampal;OLM;theta oscillations |
Data do documento: | Set-2018 |
Resumo: | Dorsal and ventral hippocampus regions exert cognition and emotion-related functions, respectively. Since both regions display rhythmic activity, specific neural oscillatory pacemakers may underlie their functional dichotomy. Type 1 theta oscillations are independent of cholinergic transmission and are observed in the dorsal hippocampus during movement and exploration. In contrast, type 2 theta depends on acetylcholine and appears when animals are exposed to emotionally laden contexts such as a predator presence. Despite its involvement in emotions, type 2 theta has not been associated with the ventral hippocampus. Here, we show that optogenetic activation of oriens-lacunosum moleculare (OLM) interneurons in the ventral hippocampus drives type 2 theta. Moreover, we found that type 2 theta generation is associated with increased risk-taking behavior in response to predator odor. These results demonstrate that two theta oscillations subtypes originate in the two hippocampal regions that predominantly underlie either cognitive or emotion-related functions. |
URI: | https://repositorio.ufrn.br/jspui/handle/123456789/25830 |
Aparece nas coleções: | ICe - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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RichardsonLeao_ICe_2018_Ventral.pdf | 7,62 MB | Adobe PDF | Visualizar/Abrir |
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