Use este identificador para citar ou linkar para este item: https://repositorio.ufrn.br/jspui/handle/123456789/25830
Título: Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor
Autor(es): Mikulovic, Sanja
Restrepo, Carlos Ernesto
Siwani, Samer
Bauer, Pavol
Pupe, Stefano
Tort, Adriano B. L.
Kullander, Klas
Leão, Richardson N.
Palavras-chave: Ventral hippocampal;OLM;theta oscillations
Data do documento: Set-2018
Resumo: Dorsal and ventral hippocampus regions exert cognition and emotion-related functions, respectively. Since both regions display rhythmic activity, specific neural oscillatory pacemakers may underlie their functional dichotomy. Type 1 theta oscillations are independent of cholinergic transmission and are observed in the dorsal hippocampus during movement and exploration. In contrast, type 2 theta depends on acetylcholine and appears when animals are exposed to emotionally laden contexts such as a predator presence. Despite its involvement in emotions, type 2 theta has not been associated with the ventral hippocampus. Here, we show that optogenetic activation of oriens-lacunosum moleculare (OLM) interneurons in the ventral hippocampus drives type 2 theta. Moreover, we found that type 2 theta generation is associated with increased risk-taking behavior in response to predator odor. These results demonstrate that two theta oscillations subtypes originate in the two hippocampal regions that predominantly underlie either cognitive or emotion-related functions.
URI: https://repositorio.ufrn.br/jspui/handle/123456789/25830
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