Navegando por Autor "Courtial, Camila Gambini Pereira"
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Artigo Anacardium occidentale L. leaves extraction via SFE: Global yields, extraction kinetics, mathematical modeling and economic evaluation(Elsevier, 2013-03-22) Leitão, Nayane Carla Márcia Cavalcanti de Sá; Prado, Helena Carvalho do; Veggi, Priscilla Carvalho; Meireles, Maria Angela Almeida; Courtial, Camila Gambini PereiraThe purpose of this work was to obtain extracts from Anacardium occidentale leaves using supercritical fluid extraction (SFE). The use of ethanol and isopropyl alcohol as co-solvents was evaluated. Mass transfer kinetics experiments were performed, and overall extraction curves were modeled. SFE process was compared with different low pressure solvent extraction processes in terms of global yield and the composition of the extract. The techniques used as low pressure solvent extraction processes were: Soxhlet extraction, agitated bed extraction, ultrasound assisted extraction using ethanol as the solvent and hydrodistillation. The extracts were analyzed by thin layer chromatography (TLC) using different eluents. Finally, the economic evaluation was conducted using the software SuperPro designer 6.0® to simulate the process and to estimate the cost of manufacturing (COM) of SFE extracts. The results indicated the presence of essential oils, lavonoids and antioxidant compounds in all the extracts. The higher yield of extract was obtained with the ultrasound assisted extraction. However, the samples with more functional compounds were verified in the SFE extracts and the extracts showed low COM. The model that best described the overall extraction curves for the SFE process was the Sovová model, which showed minimum values for the sum of the squares of the residuesArtigo Anticancer activity of Tabernaemontana catharinensis extract obtained by supercritical fluid extraction(Sociedade Brasileira de Plantas Medicinais, 2006-10-31) Courtial, Camila Gambini Pereira; Carvalho, J. E.; Meireles, Maria Angela de AlmeidaIn the present work the anticancer of crude supercritical fluid extract from T. catharinensis was evaluated. The crude extract was obtained using supercritical CO² at pressure of 300 bar and temperature of 55º C; ethanol was used as cosolvent (4.6% mass). The anticancer activity was tested against seven human cancer cell lines: lung, breast, breast expressing rhe multidrug resistance phenotype, melanoma, colon, prostate, and, kidney. The crude extract was fractionated and the alkaloidal fraction was analyzed by thin-layer chromatografy (TLC), and gas-chromatography/flame ionization detector (GC-FID). The GC-FID of the alkaloidal fraction indicated the presence of the indole alkaloids voacangine and coronaridine. The crude extract of T. catharinensis has anticancer activity that begins at 0.25 ug/mL and exhibits cytostatic and cytolytic effects concentration dependent and noy selective for the cell lines usedArtigo Aqueous two-phase systems applied to partition proteins from goat milk whey in-nature(Scientific Research Publishing, 2016-09-13) Freire, Luziany Adyja da Costa; Courtial, Camila Gambini PereiraThe proteins coming from the milk whey have numerous functional properties. Among the proteins with high bioactivity, α-lactoalbumin (α-La) and β-lactoglobulin (β-Lg) are present in large quantities in the milk whey. In the separation process of proteins, it is important to choose techniques which besides ensuring purity and high yield will not affect the molecule biological activity. The aqueous two-phase systems (ATS) have been utilized with success in the partition of these proteins, however, the studies were performed using protein in its pure form. Studies using milk whey in-nature and goat milk whey have not been found yet. In this context, the objective of this study was to evaluate the liquid liquid equilibrium of aqueous two-phase systems (ATS) in the partition of α-La and β-Lg from goat milk whey in-nature. Equilibrium data were performed considering ATS comprised of polyethylene glycol, potassium phosphate and water at 25˚C and pH 7.0. The influence of the polymer molecular weight and amount of goat milk whey in-nature on the partition coefficient of these proteins were assessed. The partition coefficient, selectivity, process yield and purity of α-lactoalbumin and β- actoglobulin proteins were determined. The results showed that the separation technique by aqueous biphasic systems is applicable indicating high efficiency in the whey proteins separation processDissertação Avaliação da conversão do óleo de soja em biodiesel utilizando álcoois de cadeia curta(Universidade Federal do Rio Grande do Norte, 2021-03-19) Costa, Talita Kênya Oliveira; Courtial, Camila Gambini Pereira; Barros Neto, Eduardo Lins de; ; http://lattes.cnpq.br/2811639726261017; ; http://lattes.cnpq.br/8055289812908100; ; http://lattes.cnpq.br/5027398357342150; Lopes, Francisco Wendell Bezerra; ; http://lattes.cnpq.br/8791819081924591; Duarte, Lindemberg de Jesus Nogueira; ; http://lattes.cnpq.br/6800188552647660O biodiesel é uma das alternativas na redução dos impactos ambientais por ser um combustível derivado de matérias primas renováveis como óleos vegetais e gorduras animais. Pode ser obtido através da reação de transesterificação entre um álcool e triglicerídeos na presença ou não de um catalisador, tendo como produto um éster, que é o biodiesel, e glicerina. O objetivo deste trabalho foi a avaliação do uso de álcoois de cadeia curta na reação de transesterificação do óleo de soja, utilizando catalisador de base homogênea (hidróxido de potássio), obtendo como resultado o modelo para a conversão da reação e a cinética reacional para o biodiesel feito com butanol. As reações de transesterificação foram realizadas em um reator de vidro encamisado, com condensador acoplado e um banho de aquecimento. Inicialmente, para estudo da conversão foram realizadas as reações com diferentes álcoois variando a razão molar álcool:óleo para o biodiesel utilizando como álcoois o metanol, etanol, 2-propanol e butanol, em seguida para avaliação das demais propriedades, foi realizado um planejamento fatorial 23 com o butanol na reação e com as seguintes condições: razão álcool:óleo de 4:1 a 8:1, 1 a 2%, 1 a 2 horas e 65°C. Para a obtenção do modelo cinético, foram selecionadas amostras entre os tempos t0 e tf (60 minutos). Para todas as amostras foram analisadas a densidade e viscosidade e suas conversões foram medidas utilizando análise termogravimétrica. Na análise de densidade, das amostras obtidas pelo planejamento fatorial, variou entre 889,41 kg/m3 e 850,18 kg/m3, já para a viscosidade variou entre 11,10 cSt e 3,10 cSt. Ao aumentar a conversão em éster, a densidade e a viscosidade sofreram decréscimo em seus valores. Para as análises de conversão, os quatro tipos de álcool com a razão molar 10:1 foram encontradas as conversões: metanol 99,28%, etanol 81,72%, 2-propanol 7,50% e butanol 49,74%. Para o planejamento com butanol, o ponto ótimo ocorreu com razão 8:1, 2% em massa de catalisador, por duas horas, onde obteve 76,24% de conversão. Com o modelo obtido pelo planejamento 23 constatou-se que os três fatores analisados foram significativos, com um erro médio entre os valores preditos e experimentais de 2,3%. A reação se mostrou de segunda ordem com constante cinética de valor 3x10-5 min-1. Sendo assim, pode-se concluir que comparando os álcoois, o metanol obteve melhor rendimento e o biodiesel produzido com butanol obteve valores de conversão condizentes com os trabalhos encontrados na literatura fazendo com que esse álcool seja uma alternativa na produção do biocombustível por advir de fontes renováveis e melhor a lubricidade do combustível.Dissertação Determinação de propriedades físico-químicas dos nades à base de açúcar, cloreto de colina e ácido cítrico(Universidade Federal do Rio Grande do Norte, 2024-02-08) Barbosa, Arthur Mathaus Varela; Courtial, Camila Gambini Pereira; Deus, Katherine Carrilho de Oliveira; https://orcid.org/0000-0003-2472-9755; http://lattes.cnpq.br/8055289812908100; http://lattes.cnpq.br/6941614988995489; Figueredo, Adolfo Lopes de; Padilha, Liana FrancoOs solventes eutéticos profundos (DES)s são conhecidos hoje como “solventes verdes”, apresentando propriedades atrativas para a indústria e atendendo as exigências atuais da Química Verde. Esses solventes são constituídos de um componente doador de ligações de hidrogênio (HBD) e outro componente receptor de ligações de hidrogênio (HBA). Uma classe importante dos DESs que tem ganhado destaque são os solventes eutéticos profundos naturais (NADES)s, provenientes de fontes naturais e de reações metabólicas fundamentais dos organismos vivos. Os NADESs possuem algumas caraterísticas desejáveis, como baixos índices de toxidez, biodegradabilidade e baixo custo, o que tem chamado a atenção dos pesquisadores para a utilização em extração líquido-líquido, eletroquímica e biocatálise. Neste estudo, foi estudado a síntese dos NADES formados por açúcares orgânicos (frutose, sacarose e glucose), ácido cítrico e cloreto de colina. Foram avaliadas as suas propriedades físico-químicas fundamentais, como: densidade, viscosidade e condutividade elétrica, em um intervalo de temperaturas entre 303 – 333 K. As propriedades de índice de refração e pH foram obtidas à 293 K e 1 atm. Essas propriedades também foram avaliadas e estudadas para dois NADESs à base de frutose e ácido cítrico com um álcool (etanol). A síntese de NADES foi realizada pelo método de aquecimento. A temperatura exerceu forte influência nas propriedades físico-químicas estudadas. O aumento da proporção molar de açúcar nos NADES resultou em um aumento nos valores de densidade, viscosidade e condutividade elétrica. O pH dos NADES, em geral, é baixo (<7), sendo a mistura ácido cítrico/cloreto de colina aquela que possui o menor valor. Os valores do índice de refração dos NADES variaram de acordo com as características de coloração de cada amostra.Artigo Determination and modeling of thermophysical and transport properties of tropical pulps(Science Publish Group, 2017-12-19) Varela, Magdiely Stefanes de Santana; Pitombeira, Gabriela Cecília Remigio; Silva, Ana Cláudia Nascimento; Courtial, Camila Gambini PereiraThe objective of this work was to determine the thermophysical and transport properties of Hancornia speciosa G. (“mangaba”), Annona muricata L. (“graviola”), Eugenia uniflora Berg (“pitanga”) pulps. The following properties were evaluated: thermal diffusivity, thermal conductivity, heat capacity, density and coefficient of thermal expansion. Rheological properties were determined and adjusted to three models. The effect of temperature on the rheological behavior was also evaluated. The pulps were further characterized in relation to humidity, ºBrix, water activity, surface tension, pH and total acidity. The results indicated agreement with literature in relation to thermophysical and transport properties, and the pulps presented a pseudoplastic behavior. Temperature influenced the pulps properties in different aspects: higher effect on the coefficient of thermal expansion of mangaba pulp, higher effect on the rheological behavior of pitanga pulp. The results presented an important advance for the knowledge of food fluids, being necessary for the processing of these materialsArtigo Determination of reactivity and thermodynamic analysis of nickel-based oxygen carriers for chemical-looping combustion(Brazilian Society of Chemical Engineering, 2019) Figueiredo, Adolfo Lopes de; Carvalho, Fabiola Correia de; Nascimento, José Carlos; Ruiz, Juan A. C.; Chiavone Filho, Osvaldo; Courtial, Camila Gambini PereiraThis work aimed to study nickel-based oxygen carriers (OC) for Chemical Looping Combustion (CLC) using H2 and CH4 as fuel. The reactivity and reaction kinetics of the OC were investigated, applying the shrinking core, nucleation and diffusion models in three dimensions, as well as whether the OC is thermodynamically favorable for the reaction. The results showed that the OC achieved high conversion for both fuels, proving to be quite reactive, while the fuel gas concentration and the temperature have a strong effect on the solids conversion. For the H2 combustion, the reaction rate can be described well by the shrinking core model, whereas for CH4 the nucleation model may better represent the experimental data. With respect to reactions that occur in the reduction reactor with the NiO/Ni redox system, it was observed that, for the investigated temperatures used in CLC, high values of the equilibrium constant were obtained, showing that practically complete conversion of the fuels is possibleArtigo Determining and modelling of thermal and rheological properties of cashew apple by-products(Science Publish Group, 2018-03-16) Vidal, Rogéria Helen Lima; Carvalho, Fábia Bocayuva; Courtial, Camila Gambini PereiraThis study aims to determine thermal and rheological properties of blended cashew apple juice (cajuína), nectar, and pulp. The effects of temperature on rheological properties were evaluated and the behavior was adjusted to rheological models. Comparing the thermal properties of cashew products, cajuína showed lower density, and higher values of thermal conductivity, thermal diffusivity and specific heat. Equations providing these properties in function of temperature were obtained, and presented good fits. Cajuína and cashew apple pulp were well characterized by the Ostwald-de-Waelle and Hershel-Bulkley models, respectively, while for cashew apple nectar, two behaviors were observed depending on the temperature usedTese Estudo da otimização do processo de hidrogenação catalítica do ácido fumárico(Universidade Federal do Rio Grande do Norte, 2022-03-25) Figueredo, Adolfo Lopes de; Courtial, Camila Gambini Pereira; Gomes, Pedro Miguel Vidinha; https://orcid.org/0000-0003-2472-9755; http://lattes.cnpq.br/8055289812908100; https://orcid.org/0000-0002-2685-2223; http://lattes.cnpq.br/2681922036812736; Braga, Tiago Pinheiro; Lopes, Francisco Wendell Bezerra; Garcia, Marco Aurélio Suller; Moura, Maria Carlenise Paiva de AlencarA produção seletiva de produtos do interesse da indústria química como γbutirolactona (GBL), tetrahidrofurano (THF) e 1,4-butanodiol (BDO) a partir da hidrogenação catalítica do ácido fumárico (Ac.FUM) é uma reação interessante no domínio da valorização da biomassa, uma vez que estes produtos podem ser considerados bioplataformas de construção molecular, funcionado como ponto de partida para inúmeros processos de síntese. Do ponto de vista da química verde, água e CO2 seriam solventes ideais, embora alcançar boas taxas de conversão e seletividade nesses meios reacionais possa ser um desafio para essa reação de hidrogenação, mesmo quando um catalisador adequado é empregado. Neste contexto, esse processo foi estudado e otimizado, primeiramente através de planejamento fatorial utilizando um catalisador a base de paládio-rênio em sílica (Pd-Re/SiO2), e um segundo catalisador a base de irídiorênio em sílica (Ir-Re/SiO2), pouco utilizado na literatura, para hidrogenação seletiva em meio aquoso de Ac.FUM em GBL. Os catalisadores foram sintetizados por impregnação úmida sequencial, e caracterizados por técnicas de DRX, TPR, ICP, TEM e análise de área superficial e volume de poros. Os produtos das reações foram identificados por GCFID e HPLC-RI. Em um segundo momento, CO2 supercrítico foi empregado como meio reacional para otimização do processo, variando a pressão entre 105-300 bar, nas condições de temperatura de 60-250 ºC. Por fim, o solvente foi avaliado considerando a seletividade da reação, onde metanol também foi utilizado nas condições 60-250 ºC e 10300 bar. Os catalisadores apresentaram porcentagem de metal de 3 % para Pd e Ir e 6 % para Re, com área superficial de 257 e 219 m2gcat-1, volume de poros de 1,31 e 1,20 cm3gcat-1 e tamanho médio das partículas de 2 e 1,5 nm, para Pd-Re e Ir-Re, respectivamente. As análises de TPR, DRX e TEM sugerem que os metais estão em contato próximo, havendo interação entre eles. Os resultados da hidrogenação do Ac.FUM utilizando os catalisadores Pd-Re/SiO2 e Ir-Re/SiO2 mostraram que GBL foi produzida com 91 e 90 % de seletividade, respectivamente, nas condições otimizadas de pressão e temperatura, previstas pelo modelo empírico, de 188 °C e 41 bar de H2 para PdRe/SiO2 e 210 °C e 25 bar de H2 para Ir-Re/SiO2. Assim, o delineamento experimental permitiu que uma alta seletividade fosse obtida em meio aquoso, proporcionando melhor racionalização do efeito combinado das variáveis temperatura e pressão. Além disso, a análise estatística no planejamento fatorial mostrou que a temperatura apresenta um maior efeito sob a seletividade da GBL em relação a pressão de H2, sendo não linear, para ambos os catalisadores. Nos estudos utilizando CO2 supercrítico foi possível modelar a atividade catalítica, suprimindo a formação de subprodutos e obtendo 89 % e 64 % de seletividade para GBL utilizando Pd-Re/SiO2 e Ir-Re/SiO2, respectivamente, nas condições de operação otimizadas. A adição do metanol como solvente promoveu alteração na composição dos produtos, obtendo THF como produto majoritário, com seletividade máxima de 97 % nas condições de 175 °C, 50 bar de H2 e 150 bar de pressão total para Pd-Re/SiO2, e 89 % nas condições de 175 °C, 50 bar de H2 e 300 bar de pressão total para Ir-Re/SiO2.Artigo Evaluation of formation processes of microcapsules by thermal analysis(International Journal of Recent Advances in Multidisciplinary Research, 2019-05-30) Maia, Juliana L.; Mata, Ana Lúcia M. L. da; Courtial, Camila Gambini PereiraAntioxidants are compounds with large industrial applicationin the pharmaceutical, cosmetic, chemical and food sectors. Anthocyanins are thermosensitive natural pigments with important antioxidant and biofunctional action, and can be better preserved if kept encapsulated. This treatment can be performed by different techniques, among them spray-dying and lyophilization. The objective of this study was to determine the thermal profile of single samples (anthocyanins and gum arabic) and materials obtained by treatment with spray-drying and lyophilization and to evaluate the efficiency of each technique in the encapsulation of anthocyanins. All samples were analyzed by Differential Scanning Calorimetry (DSC) and Scanning Electron Microscopy (SEM). The values of temperature and melting enthalpy for pure compounds and treated materials were also determined. The results showed the microparticles formation containing anthocyanins in the samples treated by spray-drying; and the thermograms obtained by DSC indicated the occurrence of encapsulation for these samples, being this result confirmed by SEM analyzesArtigo Evaluation of the lubrication of ethyl oleate and ethyl octanoate as gasoline additive(Associação Brasileira de Petróleo e Gás, 2019) Sena, S. R. C.; Barros Neto, Eduardo Lins de; Courtial, Camila Gambini PereiraThe present study assesses the effects of ethyl octanoate and ethyl oleate on the gasoline lubricity. Samples of gasoline fuel were prepared with different amounts of esters (0%, 2.5%, 5%, 10%, and 15%) and then evaluated. The lubricity tests were carried out using a High Frequency Reciprocating Test Rig (HFRR) equipment. The Wear Scar Diameter (WSD) values decreased as ester proportions increased in the samples. The percentage of lubricant film presented values above 85% for formulations with 10% and 15% ester concentration. Coefficient of friction values showed a similar behavior, they decreased as the esters fractions have increased. Results demonstrate that the esters when added to gasoline can improve the fuel lubricityArtigo Evaluation of α-Lactoalbumin and β-Lactoglobulin goat milk whey protein partition by aqueous two-phase systems using polymer/maltodextrin(Vinanie Publishers, 2019-07-01) Freire, Luziany Adyja da Costa; Courtial, Camila Gambini PereiraThe recovery of biomolecules represents an important field of study in evolution with fundamental application in the advances of biotechnology. In this work, the study of α-lactalbumin (α-La) and β-lactoglobulin (β-Lg) partitioning was carried out using aqueous two-phase systems (formed by polymer/maltodextrin) with different synthetic polymers (polyethylene glycol_PEG, polypropylene glycol_PPG, polyvinylpyrrolidone_PVP) and different molecular weights (from 425 to 40000). The influence of the type, molecular weight and percentage of the polymer used in the system was evaluated in the partition of these proteins. The results indicated that maltodextrin may be a good substitute for dextran in the processes with aqueous two phase aqueous system and it was observed that after the process the proteins tend to remain in the maltodextrin rich phaseArtigo Extraction and isolation of indole alkaloids from Tabernaemontana catharinensis A.DC: technical and economical analysis(Elsevier, 2007-03) Courtial, Camila Gambini Pereira; Rosa, Paulo de Tarso Vieira e; Meireles, Maria Angela de AlmeidaIn the present work, the technical and economical analysis of extraction and isolation of indole alkaloids from Tabernaemontana catharinensis is presented. The extraction was carried out using supercritical CO2 as solvent and ethanol as cosolvent (5%, v/v). The global yield isotherms were determined at 35 and 45 ◦C for pressures of 150–350 bar. The mass transfer rate for the constant extraction rate period (CER), the duration of the CER period, and the mass ratio of solute in the fluid phase at the bed outlet were calculated. The extraction curves were adjusted by Crank, Goto et al. and Esqu´ıvel et al. models. The economical analysis was carried out considering that the cost of manufacturing can be obtained in terms of the costs of investment, operational labor, raw material, waste treatment and utilities. The higher global yields were obtained at 350 bar (1.30×10−2 and 1.54×10−2 kg/kg, at temperatures of 35 and 45 ◦C, respectively). The Goto’s model was able to quantitatively describe the experimental data. The cost of manufacturing the extracts obtained at 350 bar, 45 ◦C, using 5% (v/v) of ethanol was US$ 79.35 kg−1 of extract. Using previous experimental data obtained at 300 bar, 55 ◦C, using 10% of ethanol (v/v), the cost of manufacturing for the fractionation process to obtain a rich alkaloidal fraction (AF) was US$ 440.31 kg−1 of alkaloidsArtigo Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid(Elsevier, 2017-11) Brandão, Gustavo Henrique Azevedo; Rigo, Graziela Vargas; Roque, A. A.; Souza, A. C. D.; Scopel, Marina; Nascimento, Cláudio Augusto Oller do; Tasca, Tiana; Courtial, Camila Gambini Pereira; Giordani, Raquel BrandtThe purpose of this study was to extract alkaloids from Melocactus zehntneri aerial parts using supercrit-ical fluid extraction (SFE) and to evaluate their cytotoxic action. SFE process was compared to differentclassical low pressure solvent extraction processes in terms of global yield, extract profile and biologicalactivity. Two specimens of M. zehntneri were evaluated: young and adult aerial parts. The extracts wereanalyzed by HPLC-UV/DAD as well as they were evaluated against HMVII and Trichomonas vaginalis. Theresults indicated a qualitative difference in chromatographic profile of the extracts. Finally, the resultspoint out the potential of the extract obtained from aerial parts of young specimens (Y-RM) through SFEat 300 bar/55◦C against T. vaginalis and HMVII, presenting relevant information for development of newstudies about cytotoxicDissertação Formação e caracterização de organogéis para veiculação de vitamina E(Universidade Federal do Rio Grande do Norte, 2023-12-11) Diniz, Grazyele Medeiros; Courtial, Camila Gambini Pereira; Deus, Katherine Carrilho de Oliveira; https://orcid.org/0000-0003-2472-9755; http://lattes.cnpq.br/8055289812908100; http://lattes.cnpq.br/4899739794226924; Figueredo, Adolfo Lopes de; https://orcid.org/0000-0002-2685-2223; http://lattes.cnpq.br/2681922036812736; Sena, Suzara Rayanne de CastroA administração de medicamentos de forma tópica além de não invasiva é uma forma fácil e vantajosa de veicular um ingrediente ativo para absorção no organismo. Além da área farmacêutica, a indústria de cosméticos também faz uso desse mecanismo de transferência de materiais de maneira a prevenir a degradação por ação de interação com outros compostos antes da passagem pela pele. Dentre os diversos meios de veiculação de materiais bioativos, os organogéis vêm se destacado como materiais com estrutura atrativa para a liberação controlada de compostos bioativos. Estes materiais são semissólidos formados pela mistura de pequenas concentrações de gelator (< 15 %) e solvente orgânico. Em paralelo, um ativo de interesse nessas áreas é a vitamina E, um importante nutriente lipossolúvel, que apresenta propriedades antioxidantes, umectantes, emolientes, dentre outras. Nesse contexto, esse estudo objetiva preparar e caracterizar organogéis para veiculação da vitamina E para aplicações na indústria de cosméticos e farmacêutica. Óleo de coco (OCO), óleo de canola (OCA) e ácido oleico (AO) foram investigados como solventes orgânicos, enquanto Tween 80 (T80) e PEG 300 (P300) foram investigados como gelators. Primeiramente, foi estudado o comportamento de fases dos sistemas para construção dos diagramas pseudoternários. Em seguida, a vitamina E foi incorporada aos géis e essas formulações foram caracterizadas através de análises de tamanho de partícula, índice de polidispersão, pH e reologia para avaliar a estabilidade e potencial de veiculação da vitamina E através dos géis. Por fim, avaliou-se a possibilidade de quantificação da vitamina E nas formulações através da técnica de espectrofotometria UV. A partir dos testes de solubilidade das misturas binárias de gelator e solvente orgânico, T80 foi selecionado como gelator para a continuação do estudo e foram obtidos os diagramas ternários dos sistemas OCO/T80/água, OCA/T80/água e AO/T80/água. Em seguida, os géis obtidos com menor concentração de T80 em cada sistema foram caracterizados. A análise da distribuição dos tamanhos de partículas, as medidas de pH e o estudo reológico indicaram que as formulações avaliadas são promissoras, pois apresentam as características desejadas para aplicações cosméticas para a veiculação da vitamina E. Por fim, a espectrofotometria UV não foi adequada para quantificar a vitamina E incorporada nos géis, devido a interferência causada pelos excipientes na absorção de radiação UV no mesmo comprimento de onda que a vitamina E.Artigo From biomass to bio-oil: processes and treatments to convert raw material into energy(SSRG - IJCER Journal, 2018-09) Sena, Suzara Rayanne de Castro; Courtial, Camila Gambini PereiraBio-oil is a potential fuel obtained from pyrolysis of biomass. This work provides a discussion about the different processes used to obtain this product, evidencing the factors that influence its properties and characteristics. A comparison of the properties of bio-oils with traditional fuels is presented. As well as this, the main treatments to upgrade biooil are also discussedArtigo Functional food formulation by the addition of whole grain flour and linseed(Journal of Food Industry, 2017-12-08) Bakker, Christiane Maria Christina Nobrega; Courtial, Camila Gambini PereiraRecommendations for consuming industrialized whole grain foods have been encouraged. The present study produced new functional foods and sought to identify the sensory profile of the foods processed. Four types of dried spaghetti were manufactured with different formulas, regarding their whole grain flour and linseed content (10 and 20%). For evaluation of the products obtained, the following methods were employed: sensory analysis of acceptance using a 9-point hedonic scale, applied to 50 trained judges, and Quantitative Descriptive Analysis (QDA) using a 9-cm unstructured line scale. Results were analyzed by ANOVA and Tukey’s test at 5% significance, and the sensory profile was expressed in the form of a spider graph. Acceptance test revealed no difference between the pasta containing 10% and 20% of whole grain and 10% of linseed. Results indicate acceptance of the 20% whole grain product regarding its raw texture and consistency when cooked, in addition to the possibility for the manufacture and acceptance of 10% linseed spaghettiArtigo Guaiacol and its mixtures: New data and predictive models part 1: Phase equilibrium(Elsevier, 2018-08-25) Courtial, Camila Gambini Pereira; Féjean, Christophe; Betoulle, Stéphane; Ferrando, Nicolas; Lugo, Rafael; Hemptinne, Jean Charles de; Mougin, PascalIn the present work, new experimental data of guaiacol mixture with methane were investigated. The results have been evaluated using several thermodynamic approaches. Predictive calculations using the GC-PPC-SAFT (Group Contribution-Polar Perturbed Chain- Statistical Associating Fluid Theory) equation of state and Molecular Simulation using the Anisotropic United Atoms (AUA4) force field were performed. Data from literature for the binary systems of guaiacol with CO2, ethanol, octanol, acetone, butyl acetate and water were used to evaluate the thermodynamic models. The effect of the association scheme is discussed at length. Predictive phase equilibrium for systems containing small and toxic compounds, such as hydrogen, carbon monoxide, hydrogen sulfide and ammonia were also performed. In GC-PPC-SAFT, two configurations of associative sites for guaiacol were considered. The predicted values showed to be consistent with new experimental data. The effect of conformational structure of guaiacol on phase equilibria was detectedArtigo Leishmanicidal activity of a supercritical fluid fraction obtained from Tabernaemontana catharinensis(Elsevier, 2007-06) Soares, Deivid Costa; Courtial, Camila Gambini Pereira; Meireles, Maria Angela de Almeida; Saraiva, Elvira MariaThe branches and leaves of Tabernaemontana catharinensis were extracted with supercritical fluid using a mixture of CO2 plus ethanol (SFE), and the indole alkaloid enriched fraction (AF3) was selected for anti-Leishmania activity studies. We found that AF3 exhibits a potent effect against intracellular amastigotes of Leishmania amazonensis, a causative agent of New World cutaneous leishmaniasis. AF3 inhibits Leishmania survival in a dose-dependent manner, and reached 88% inhibition of amastigote growth at 100 μg/mL. The anti-parasite effect was independent of nitric oxide (NO), since AF3 was able to inhibit NO production induced by IFN-γ plus LPS. In addition, AF3 inhibited TGF-β production, which could have facilitated AF3-mediated parasite killing. The AF3 fraction obtained from SFE was nontoxic for host macrophages, as assessed by plasma membrane integrity and mitochondrial activity. We conclude that SFE is an efficient method for obtaining bioactive indole alkaloids from plant extracts. Importantly, this method preserved the alkaloid properties associated with inhibition of Leishmania growth in macrophages without toxicity to host cellsArtigo Modeling and simulation of paraffin solubility in circular pipes in laminar regime flow(Elsevier, 2016-05) Oliveira, Erika Cristina Lourenço de; Barros Neto, Eduardo Lins de; Courtial, Camila Gambini PereiraThe paraffinic wax deposition of the crude oil reduces pipe’s flow area, causing, consequently, larger costs for the oil industry. The solubilization of paraffin using solvents is a viable solution, especially in pipes within treatment plants and oil processing, where use other methods has been restricted, such as the “pig”. This paper proposes a method to calculate the paraffin wax solubility in solvent, based on solid–liquid thermodynamic approach for this was proposed a discredited mathematical model for heat and mass transfer. The simplified model is able to successfully reproduce many of the known trends of the paraffin solubility. These models were implemented in programming software, where it was possible to obtain results, as variations in the length of pipe, type of solvent and inlet temperature. The models produced adequate solutions, maintaining continuity of differential energy and mass balance equations, with a viable physical interpretation