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Title: Baccharis trimera (Less.) DC exhibits an anti-Adipogenic effect by inhibiting the expression of proteins involved in adipocyte differentiation
Authors: Nascimento, Daniele de Souza Marinho do
Oliveira, Ruth Medeiros
Câmara, Rafael Barros Gomes da
Gomes, Dayanne Lopes
Monte, Jessika Fernanda Santiago
Costa, Mariana Santana Santos Pereira
Fernandes, Júlia Moraes
Langassner, Silvana Maria Zucolotto
Rocha, Hugo Alexandre de Oliveira
Keywords: Adipogenesis;Antioxidant;Chlorogenic acid
Issue Date: 12-Jun-2017
Publisher: MDPI
Citation: NASCIMENTO, Daniele de Souza Marinho do; OLIVEIRA, Ruth Medeiros; CAMARA, Rafael Barros Gomes da; GOMES, Dayanne Lopes; MONTE, Jessika Fernandes Santiago; COSTA, Mariana Santana Santos Pereira; FERNANDES, Júlia Moraes; LANGASSNER, Silvana Maria Zucolotto; ROCHA, Hugo Alexandre Oliveira. Baccharis trimera (Less.) DC exhibits an anti-Adipogenic effect by inhibiting the expression of proteins involved in adipocyte differentiation. Molecules, [s. l.], v. 22, n. 6, p. 972, 12 jun. 2017. MDPI AG. Disponível em: Acesso em: 04 ago. 2020.
Portuguese Abstract: Baccharis trimera (Less.) DC (gorse) is a plant popularly used for the treatment of obesity. In this study, we prepared three B. trimera extracts aqueous extract (AE), decoction (AE-D), and methanol extract (ME) and investigated their antioxidant effects in six different tests and their anti-adipogenic effect in 3T3-L1 cells. The extracts showed a dose-dependent antioxidant activity in all tests. AE was the most potent antioxidant in copper and ferric ion chelation assays, whereas AE-D was the most potent in superoxide and hydroxyl radical scavenging assays, reducing power assay, and total antioxidant capacity analysis. Only ME showed a cytotoxic effect against 3T3-L1 cells. Lipid accumulation decreased in 3T3-L1 adipocytes in the presence of AE and AE-D extracts (0.5 to 1.0 mg/mL). In addition, the extracts dramatically attenuated the levels of adipogenic transcriptional factors, including CCAAT enhancer-binding protein α (C/EBPα), CCAAT enhancer-binding protein β (C/EBPβ), and gamma receptors by peroxisome proliferators (PPARγ), during adipogenesis. AE-D (1.0 mg/mL) caused an approximately 90% reduction in the levels of these molecules. We propose that B. trimera has an anti-adipogenic effect and could be used in the development of functional foods
ISSN: 1420-3049 (online)
Appears in Collections:CB - DBQ - Artigos publicados em periódicos
CCS - DFAR - Artigos publicados em periódicos
EMCM - Artigos publicados em periódicos

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