Please use this identifier to cite or link to this item:
Title: Immunohistochemical Detection of Receptor Activator Nuclear κB Ligand and Osteoprotegerin in Odontogenic Cysts and Tumors
Authors: Matos, Felipe Rodrigues de
Moraes, Maiara de
Silva, Emília Beatriz das Neves
Galvão, Hebel Cavalcanti
Freitas, Roseana de Almeida
Keywords: Immunohistochemistry;Adenomatoid odontogenic tumors;Cysts
Issue Date: 2013
Citation: MATOS, Felipe Rodrigues de et al . Immunohistochemical Detection of Receptor Activator Nuclear κB Ligand and Osteoprotegerin in Odontogenic Cysts and Tumors. Journal of Oral and Maxillofacial Surgery, v. 71, n. 11, p. 1886-1892, 2013.
Portuguese Abstract: Purpose The aim of the present study was to compare the immunohistochemical detection of receptor activator nuclear κB ligand (RANKL) and osteoprotegerin (OPG) in radicular cysts (RCs), dentigerous cysts (DCs), solid ameloblastomas (SAs), and keratocystic odontogenic tumors (KOTs). Materials and Methods A total of 20 RCs, 20 DCs, 20 KOTs, 14 dental follicles (DFs), and 18 SAs were evaluated by immunohistochemistry using anti-RANKL and anti-OPG antibodies. The analysis was quantitative, and the number of positive cells was counted in 10 microscopic high-power fields (400×). Results The DFs, KOTs, and SAs showed higher expression of RANKL than did the RCs and DCs in the epithelium (P < .05). The epithelial expression of OPG was higher in the DFs, KOTs, RCs, and DCs than in the SAs (P < .05). The ratio of OPG less than RANKL was more frequent in SAs and OPG greater than RANKL in DCs (P < .05). Conclusions Our results have shown differences in RANKL and OPG detection in the odontogenic cysts and tumors studied. The higher RANKL and lower OPG detection in SA could play a role in bone resorption, compatible with the tumor's biologic behavior.
Appears in Collections:CCS - DOD - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
Immunohistochemical Detection of Receptor Activator_2013.pdf,94 MBAdobe PDFThumbnail

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.