Use este identificador para citar ou linkar para este item:
https://repositorio.ufrn.br/handle/123456789/23803| Título: | Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study |
| Autor(es): | Pereira, Joabe dos Santos Fontes, Fabrícia Lima Medeiros, Sílvia Regina Batistuzzo de Freitas, Roseana de Almeida Souza, Lélia Batista de Miguel, Márcia Cristina da Costa |
| Palavras-chave: | DNA repair.;Genetic polymorphisms.;Oral cancer.;Restriction fragment length polymorphisms.;Squamous cell carcinoma. |
| Data do documento: | 2016 |
| Editor: | ELSEVIER |
| Referência: | PEREIRA, Joabe dos Santos et al . Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study. Archives of Oral Biology, v. 64, p. 19-23, 2016. |
| Resumo: | Objective to evaluate the association between XPD and XRCC3 polymorphisms and oral squamous cell carcinoma (OSCC). Design the sample consisted of 54 cases of OSCC and 40 cases of inflammatory fibrous hyperplasia (IFH). Genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results XPD-Lys/Gln was more common in IFH (n = 28; 70%) than in OSCC (n = 24; 44.4%) (OR: 0.3; p < 0.05). XPD-Gln was more frequent in high-grade lesions (0.48) than in low-grade lesions (0.21) (OR: 3.4; p < 0.05). The Gln/Gln genotype was associated with III and IV clinical stages (OR: 0.07; p < 0.05). XRCC3-Met was more frequent in OSCC (0.49) than in IFH (0.35) (OR: 2.6; p < 0.05). The Met/Met genotype was associated with the presence of metastases (OR: 8.1; p < 0.05) and with III and IV clinical stages (OR: 0.07; p < 0.05). Conclusions in this sample, the frequency of XPD-Gln in IFH suggests that this variant may protect against OSCC. The presence of the XRCC3-Met allele seems to contribute to the development of OSCC, metastases and more advanced stages in these lesions. |
| URI: | https://repositorio.ufrn.br/jspui/handle/123456789/23803 |
| Aparece nas coleções: | CCS - DOD - Artigos publicados em periódicos |
Arquivos associados a este item:
Não existem arquivos associados a este item.
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.